RECRUITING

A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

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Conditions

Chronic Obstructive Pulmonary Disease (COPD)

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will evaluate the efficacy and safety of astegolimab compared with placebo in participants with chronic obstructive pulmonary disease (COPD) who are former or current smokers and have a history of frequent exacerbations.

Official Title

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease

Quick Facts

Study Start:2022-12-29
Study Completion:2025-06-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05595642

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Reference Study ID Number: GB44332 https://forpatients.roche.com/
CONTACT
888-662-6728
global-roche-genentech-trials@gene.com

Principal Investigator

Clinical Trials
STUDY_DIRECTOR
Hoffmann-La Roche

Study Locations (Sites)

Pinnacle Research Group
Anniston, Alabama, 36207-4781
United States
AllerVie Clinical Research
Birmingham, Alabama, 35209-6802
United States
Synexus Clinical Research US, Inc. - Birmingham
Birmingham, Alabama, 35211-1320
United States
University of Alabama at Birmingham
Birmingham, Alabama, 35294
United States
SEC Clinical Research LLC - Dothan 2 - ClinEdge - PPDS
Dothan, Alabama, 36305
United States
Pulmonary Associates of Mobile PC
Mobile, Alabama, 36608-3135
United States
Pulmonary Associates
Glendale, Arizona, 85306-4669
United States
Synexus Clinical Research US, Inc. - Phoenix West
Glendale, Arizona, 85306-4678
United States
AES - DRS - Synexus Clinical Research US, Inc. - Tucson
Tucson, Arizona, 85741-3118
United States
Lynn Institute of The Ozarks - ERN - PPDS
Little Rock, Arkansas, 72204-1505
United States
Kern Research
Bakersfield, California, 93301
United States
Chemidox Clinical Trials Inc QCR HyperCore -PPDS
Lancaster, California, 935342839
United States
VA Palo Alto Health Care System
Palo Alto, California, 94304
United States
AES - DRS - Synexus Clinical Research US, Inc. - Vista
Vista, California, 92083-6051
United States
Allergy & Asthma Medical Group of the Bay Area
Walnut Creek, California, 94598
United States
Emerson Clinical Research Institute LLC - Connecticut Ave - DC - ECRI - HyperCore - PPDS
Washington, Connecticut, 20009-1148
United States
Meris Clinical Research
Brandon, Florida, 33511-5719
United States
Invictus Clinical Research Group, LLC
Coconut Creek, Florida, 33073-3458
United States
UF Health Pulmonary
Gainesville, Florida, 32610-3008
United States
Finlay Medical Research Corporation
Greenacres City, Florida, 33467-2979
United States
Finlay Medical Research Corporation
Greenacres City, Florida, 33467-2979
United States
Cornerstone Research Institute
Longwood, Florida, 32750-5307
United States
San Marcus Research Clinic Inc.
Miami, Florida, 33014
United States
Oceane7 Medical & Research Center, Inc.
Miami, Florida, 33144-2155
United States
Avantis Clinical Research, LLC
Miami, Florida, 33155-3265
United States
Research Institute of South Florida Inc
Miami, Florida, 33173-4648
United States
Diverse Clinical Research, LLC
Miami, Florida, 33175-3434
United States
Central Florida Pulmonary Group, PA
Orlando, Florida, 32803
United States
Revival Clinical Research
Orlando, Florida, 32807
United States
Florida Institute for Clinical Research, LLC
Orlando, Florida, 32822
United States
Ormond Beach Clinical Research
Ormond Beach, Florida, 32174-8196
United States
Tampa Bay Health Care
Tampa, Florida, 33614-3221
United States
AES - DRS - Synexus Clinical Research US, Inc. - The Villages
The Villages, Florida, 32162-7116
United States
Cleveland Clinic Florida
Weston, Florida, 33331
United States
AES - DRS - Synexus Clinical Research US, Inc. - Atlanta
Atlanta, Georgia, 30328
United States
Allergy Center at Brookstone Research - Centricity Research - HyperCore - PPD
Columbus, Georgia, 31904-2954
United States
Pivotal Research Solutions
Stonecrest, Georgia, 30038-2649
United States
ASHA Clinical Research - ClinEdge - PPDS
Hammond, Indiana, 46324-2213
United States
The Research Group of Lexington, LLC
Lexington, Kentucky, 40504
United States
University of Louisville Research Foundation
Louisville, Kentucky, 40202
United States
Best Clinical Trials
New Orleans, Louisiana, 70115-3677
United States
Paul A. Shapero, MD, PA
Bangor, Maine, 04401-5691
United States
Pulmonary Research Institute of Southeast Michigan
Farmington Hills, Michigan, 48336-2817
United States
Aa Mrc Llc
Flint, Michigan, 48504-4730
United States
Revive Research Institute-32256 Northwestern Hwy
Lathrup Village, Michigan, 48076
United States
Revive Research Institute
Lathrup Village, Michigan, 48076
United States
Oakland Medical Research Center
Madison Heights, Michigan, 48071
United States
Midwest Chest Consultants
Saint Charles, Missouri, 63301
United States
Saint Louis Veterans Affairs Medical Center - NAVREF - PPDS
Saint Louis, Missouri, 63106-1621
United States
Washington University School of Medicine in St. Louis
Saint Louis, Missouri, 63110
United States
Nebraska Medical Research Institute, Inc. - CRN
Bellevue, Nebraska, 68123
United States
The Machuca Foundation Inc
Las Vegas, Nevada, 89104-3953
United States
Renown Regional Medical Center Hospital
Reno, Nevada, 89502-1576
United States
Hassman Research Institute - HRI - Berlin - CenExel - PPDS
Berlin, New Jersey, 08009-9263
United States
UniMed Center LLC
East Brunswick, New Jersey, 08816-1407
United States
Providence Medical Center Noth Plainfield - 25 Cra
North Plainfield, New Jersey, 07060-4777
United States
Urban Health Plan, Inc.
Bronx, New York, 10459
United States
VA Western New York Healthcare System - NAVREF - PPDS
Buffalo, New York, 14215-1129
United States
Parker Jewish Institute
New Hyde Park, New York, 11040-1436
United States
AES - DRS - Synexus Clinical Research US, Inc. - New York
New York, New York, 10017-4008
United States
WellNow Urgent Care and Clinical Research - Niskayuna
Schenectady, New York, 12304-2268
United States
Research Carolina Elite
Denver, North Carolina, 28037-7929
United States
Duke Asthma Allergy and Airway Center
Durham, North Carolina, 27705-2671
United States
Care Access Research - Fayetteville - PPDS
Fayetteville, North Carolina, 28314-0260
United States
Clinical Research of Gastonia
Gastonia, North Carolina, 28054
United States
Pulmonix LLC
Greensboro, North Carolina, 27403
United States
Advanced Respiratory and Sleep Medicine, PLLC
Huntersville, North Carolina, 28078
United States
Southeastern Research Center
Winston-Salem, North Carolina, 27103-4029
United States
Wellnow Urgent Care and Research ? Springdale
Cincinnati, Ohio, 45215-1170
United States
WellNow Urgent Care & Research - Huber Heights
Huber Heights, Ohio, 45424-4019
United States
Toledo Inst of Clin Research
Toledo, Ohio, 43617
United States
OK Clinical Research
Edmond, Oklahoma, 73034
United States
Vital Prospects Clinical Research Institute PC - CRN
Tulsa, Oklahoma, 74136
United States
The Oregon Clinic
Portland, Oregon, 97213
United States
Clinical Research Associates Of Central Pa , Llc
DuBois, Pennsylvania, 15801
United States
Allergy & Clinical Immun Assoc
Pittsburgh, Pennsylvania, 15241-1041
United States
Medtrial, LLC
Columbia, South Carolina, 29204
United States
Velocity Clinical Research - Gaffney - PPDS
Gaffney, South Carolina, 29340-4737
United States
Care Access Research - Mauldin - PPDS
Mauldin, South Carolina, 29662
United States
ClinSearch, LLC
Chattanooga, Tennessee, 37421
United States
Clinical Trials Center of Middle Tennessee
Franklin, Tennessee, 37067-5663
United States
Tennessee Comprehensive Lung & Sleep Center
Hendersonville, Tennessee, 37075-3085
United States
FutureSearch Trials of Neurology
Austin, Texas, 78731-4915
United States
TTS Research
Boerne, Texas, 78006
United States
Corsicana Medical Research
Corsicana, Texas, 75110-2471
United States
Baylor University Medical Center
Dallas, Texas, 75231
United States
Epic Medical Research LLC - DeSoto
DeSoto, Texas, 75115
United States
Greater Heights Memorial Pulmonary and Sleep
Houston, Texas, 77008-1592
United States
Trio Clinical Trials
Houston, Texas, 77008-1772
United States
Baylor College of Medicine Medical Center
Houston, Texas, 77030
United States
Methodist Hospital Research Institute
Houston, Texas, 77030
United States
Uni of Texas Health Science Center At Houston
Houston, Texas, 77030
United States
Clinical Trial Network
Houston, Texas, 77074
United States
Advances In Health Inc
Houston, Texas, 77089-5716
United States
Biopharma Informatic - Park Row - PPDS
Houston, Texas, 77089-6097
United States
R & H Clinical Research
Katy, Texas, 77494-2031
United States
R & H Clinical Research
Katy, Texas, 77494-2031
United States
University of Utah Hospitals & Clinics
Salt Lake City, Utah, 84132
United States
University of Vermont Medical Center
Burlington, Vermont, 05401
United States
Virginia Research Center, LLC
Midlothian, Virginia, 23114-3256
United States
Western Washington Medical Group
Everett, Washington, 98208
United States
Allergy Asthma and Sinus Center-Greenfield
Greenfield, Wisconsin, 53228-3467
United States

Collaborators and Investigators

Sponsor: Hoffmann-La Roche

  • Clinical Trials, STUDY_DIRECTOR, Hoffmann-La Roche

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-12-29
Study Completion Date2025-06-01

Study Record Updates

Study Start Date2022-12-29
Study Completion Date2025-06-01

Terms related to this study

Additional Relevant MeSH Terms

  • Chronic Obstructive Pulmonary Disease (COPD)