Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB

Description

This study aims to examine the longer-term benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program (PACR-CT) five years from the initial 10 weeks of training from our Phase II study - Protocol #: PSC-0605-17 (Aim 1) and test the interactive effect of previous training and 10 weeks of booster training (Aim 2). Both the study and the software being investigated meet the criteria of Non-Significant Risk.

Conditions

Age-related Cognitive Decline

Study Overview

Study Details

Study overview

This study aims to examine the longer-term benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program (PACR-CT) five years from the initial 10 weeks of training from our Phase II study - Protocol #: PSC-0605-17 (Aim 1) and test the interactive effect of previous training and 10 weeks of booster training (Aim 2). Both the study and the software being investigated meet the criteria of Non-Significant Risk.

BETTER Aging Trial: Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB

Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB

Condition
Age-related Cognitive Decline
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Dallas

University of Texas at Dallas, Dallas, Texas, United States, 75235

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participant must be 70 years of age or older
  • * Participant must be a fluent English speaker
  • * Participant must have adequate sensorimotor capacity to perform the program, including visual capacity adequate to read from a computer screen at a normal viewing distance, auditory capacity adequate to understand normal speech, and motor capacity adequate to control a computer mouse
  • * Participant must not have evidence of dementia as indicated by the Montreal Cognitive Assessment (MoCA)
  • * Participant with any medical illnesses, injuries or conditions predisposing to imminent functional and/or cognitive decline
  • * Participant requiring caregiver assistance in dressing/personal hygiene
  • * Participant with severe visual deficits (including visual neglect, partial field cuts, anopias) and/or severe hearing deficit that would prevent use of the computerized treatment program
  • * Participant with recent participation of computer-delivered cognitive training within 2 years of consent
  • * Participant with claustrophobia or any other contraindication to MRI scanning
  • * Participant with inability to complete a 1-hour MRI
  • * Pregnant women
  • * Participant with any implanted devices above the waist (e.g., cardiac pacemaker or auto-defibrillators, neural pacemaker, aneurysm clips, cochlear implant, metallic bodies in the eye or central nervous system, any form of wires or metal devices that may concentrate radio frequency fields)
  • * Participants with active suicidal ideation with specific plan and intent or suicide-related behaviors within 2 months of consent as measured by the Columbia-Suicide Severity Rating Scale (C-SSRS)

Ages Eligible for Study

70 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Posit Science Corporation,

Hyun Kyu Lee, PhD, PRINCIPAL_INVESTIGATOR, Posit Science Corporation

Study Record Dates

2026-04-01