RECRUITING

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

Conditions

B-cell Malignancy Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma Waldenstrom Macroglobulinemia Mantle Cell Lymphoma Marginal Zone Lymphoma Follicular Lymphoma Non-Hodgkin Lymphoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is an open-label, multi-center Phase 1b clinical study of oral AS-1763 (docirbrutinib) in patients with CLL/SLL or B-cell NHL who have failed or are intolerant to ≥2 lines of systemic therapy.

Official Title

A Phase 1b Study of Oral AS-1763 in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

Quick Facts

Study Start:2023-08-01

Study Completion:2027-09

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05602363

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age ≥18 years * Provided written informed consent * Histologically confirmed B-cell malignancy, including CLL/SLL, WM, MCL, MZL, or FL * Patients with SLL, MCL, MZL, and FL: at least 1 radiographically measurable lesion * Failed or are intolerant to ≥2 prior lines of systemic therapy * ECOG Performance Status 0 to 2 * Adequate hematologic status (ie, absolute neutrophil count ≥0.75 × 10⁹/L, platelet count ≥50 × 10⁹/L, hemoglobin ≥8 g/dL) not requiring transfusion support or growth factors * Adequate hepatic function * Adequate renal function * Ability to swallow tablets and comply with study requirements for the duration of study participation * Male and female patients of reproductive potential: Willing to observe conventional and effective birth control methods * Male patients: agree not to donate sperm during and for 6 months after the study * Dose Expansion Cohort 3 patients: prior treatment with pirtobrutinib (Jaypirca) for an approved indication	* Transformed disease (eg, Richter's transformation) prior to or during Screening * Investigational agent or anticancer therapy within 5 half-lives before the planned start of docirbrutinib, except therapeutic monoclonal antibody treatment which must be discontinued at least 4 weeks before the start of docirbrutinib * Current treatment with investigational therapy or planned investigational therapy which would be concurrent with this study * Requiring therapeutic anticoagulation with warfarin * Current treatment with certain strong CYP3A4 inhibitors or inducers * Treatment with proton pump inhibitors within 7 days before first dose of docirbrutinib * Current treatment with strong P-glycoprotein inhibitors or strong BCRP inhibitors * Refractory to transfusion support * Major surgery within 4 weeks before planned start of docirbrutinib * Radiotherapy with a limited field of radiation for palliation within 7 days of the first dose of study treatment * Any unresolved toxicities from prior therapy greater than NCI CTCAE Version 5.0 Grade 2 at the time of starting study treatment except for alopecia * History of allogeneic or autologous stem cell transplant or CAR-T therapy within the last 30 days * Active second malignancy unless in remission with life expectancy \>2 years * Known central nervous system (CNS) involvement by systemic lymphoma * Active uncontrolled autoimmune cytopenia (eg, autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura) where new therapy introduced or concomitant therapy escalated within the 4 weeks before study enrollment is required to maintain adequate blood counts * Clinically significant, uncontrolled cardiac, cardiovascular disease or history of myocardial infarction within 6 months before planned start of docirbrutinib, or prolongation of the QT interval corrected for heart rate using Fridericia's Formula (QTcF) \>470 msec on at least 2 of 3 consecutive ECGs, and mean QTcF \>470 msec on all 3 ECGs, during Screening * Active uncontrolled systemic bacterial, viral, fungal, or parasitic infection * Positive for HIV. For patients with unknown HIV status, HIV testing will be performed at Screening * Clinically significant active malabsorption syndrome or other condition likely to affect gastrointestinal absorption of docirbrutinib * Pregnant or lactating. * Known hypersensitivity to any component or excipient of docirbrutinib * Prior treatment with docirbrutinib * Dose Escalation and Cohort 3 patients: prior treatment with noncovalent BTKi except pirtobrutinib (Jaypirca) * Dose Expansion Cohort 1 and Cohort 2 patients: prior treatment with any noncovalent BTKi

Inclusion Criteria

Exclusion Criteria

* Age ≥18 years
* Provided written informed consent
* Histologically confirmed B-cell malignancy, including CLL/SLL, WM, MCL, MZL, or FL
* Patients with SLL, MCL, MZL, and FL: at least 1 radiographically measurable lesion
* Failed or are intolerant to ≥2 prior lines of systemic therapy
* ECOG Performance Status 0 to 2
* Adequate hematologic status (ie, absolute neutrophil count ≥0.75 × 10⁹/L, platelet count ≥50 × 10⁹/L, hemoglobin ≥8 g/dL) not requiring transfusion support or growth factors
* Adequate hepatic function
* Adequate renal function
* Ability to swallow tablets and comply with study requirements for the duration of study participation
* Male and female patients of reproductive potential: Willing to observe conventional and effective birth control methods
* Male patients: agree not to donate sperm during and for 6 months after the study
* Dose Expansion Cohort 3 patients: prior treatment with pirtobrutinib (Jaypirca) for an approved indication

* Transformed disease (eg, Richter's transformation) prior to or during Screening
* Investigational agent or anticancer therapy within 5 half-lives before the planned start of docirbrutinib, except therapeutic monoclonal antibody treatment which must be discontinued at least 4 weeks before the start of docirbrutinib
* Current treatment with investigational therapy or planned investigational therapy which would be concurrent with this study
* Requiring therapeutic anticoagulation with warfarin
* Current treatment with certain strong CYP3A4 inhibitors or inducers
* Treatment with proton pump inhibitors within 7 days before first dose of docirbrutinib
* Current treatment with strong P-glycoprotein inhibitors or strong BCRP inhibitors
* Refractory to transfusion support
* Major surgery within 4 weeks before planned start of docirbrutinib
* Radiotherapy with a limited field of radiation for palliation within 7 days of the first dose of study treatment
* Any unresolved toxicities from prior therapy greater than NCI CTCAE Version 5.0 Grade 2 at the time of starting study treatment except for alopecia
* History of allogeneic or autologous stem cell transplant or CAR-T therapy within the last 30 days
* Active second malignancy unless in remission with life expectancy \>2 years
* Known central nervous system (CNS) involvement by systemic lymphoma
* Active uncontrolled autoimmune cytopenia (eg, autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura) where new therapy introduced or concomitant therapy escalated within the 4 weeks before study enrollment is required to maintain adequate blood counts
* Clinically significant, uncontrolled cardiac, cardiovascular disease or history of myocardial infarction within 6 months before planned start of docirbrutinib, or prolongation of the QT interval corrected for heart rate using Fridericia's Formula (QTcF) \>470 msec on at least 2 of 3 consecutive ECGs, and mean QTcF \>470 msec on all 3 ECGs, during Screening
* Active uncontrolled systemic bacterial, viral, fungal, or parasitic infection
* Positive for HIV. For patients with unknown HIV status, HIV testing will be performed at Screening
* Clinically significant active malabsorption syndrome or other condition likely to affect gastrointestinal absorption of docirbrutinib
* Pregnant or lactating.
* Known hypersensitivity to any component or excipient of docirbrutinib
* Prior treatment with docirbrutinib
* Dose Escalation and Cohort 3 patients: prior treatment with noncovalent BTKi except pirtobrutinib (Jaypirca)
* Dose Expansion Cohort 1 and Cohort 2 patients: prior treatment with any noncovalent BTKi

Contacts and Locations

Study Contact

Akinori Arimura, PhD

CONTACT

650-636-4603

clinical_us@dd.carnabio.com

Study Locations (Sites)

UC Irvine Health

Orange, California, 92868

United States

Mount Sinai Comprehensive Cancer Center

Miami Beach, Florida, 33140

United States

Moffitt Cancer Center

Tampa, Florida, 33612

United States

Northwestern Memorial Hospital

Chicago, Illinois, 60661

United States

University of Maryland Medical Center - Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, 21201

United States

University of Massachusetts Memorial Medical Center

Worcester, Massachusetts, 01655

United States

Clinical Research Alliance, Inc.

Westbury, New York, 11590

United States

University of Texas MD Anderson Cancer Center

Houston, Texas, 77030

United States

The Medical College of Wisconsin

Milwaukee, Wisconsin, 53266

United States

Collaborators and Investigators

Sponsor: Carna Biosciences, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-01

Study Completion Date2027-09

Study Record Updates

Study Start Date2023-08-01

Study Completion Date2027-09

Terms related to this study

Additional Relevant MeSH Terms

B-cell Malignancy
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Waldenstrom Macroglobulinemia
Mantle Cell Lymphoma
Marginal Zone Lymphoma
Follicular Lymphoma
Non-Hodgkin Lymphoma