MRI in Transcatheter Aortic Valve Replacement Patients

Description

The hypothesis is that SEV result in superior valvular hemodynamics (more pronounced during exercise) and exercise capacity relative to BEV. Furthermore, the hypothesis is that stress CMR will be able to demonstrate differences in these hemodynamic parameters. CMR will also provide refined assessment of paravalvular leak and its impact on ventricular function and on clinical outcomes.

Conditions

Aortic Valve Stenosis

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Study Overview

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Study Details

Study overview

The hypothesis is that SEV result in superior valvular hemodynamics (more pronounced during exercise) and exercise capacity relative to BEV. Furthermore, the hypothesis is that stress CMR will be able to demonstrate differences in these hemodynamic parameters. CMR will also provide refined assessment of paravalvular leak and its impact on ventricular function and on clinical outcomes.

Comparison of Hemodynamic Performance of Transcatheter Aortic Valve Replacement With Supra-Annular Self-Expanding Versus Balloon-Expandable Valves Assessed by Exercise Cardiovascular Magnetic Resonance

MRI in Transcatheter Aortic Valve Replacement Patients

Condition
Aortic Valve Stenosis
Intervention / Treatment

-

Contacts and Locations

Cleveland

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States, 44106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aortic valve stenosis with clinical indication for valve replacement decided by a dedicated heart team;
  • * Planned transfemoral TAVR; 18 years of age or older;
  • * Able to give informed consent.
  • * Patients with permanent pacemakers or implantable defibrillators;
  • * Patients with non-MRI safe implants;
  • * Severe claustrophobia;
  • * Inability or contraindication to perform exercise bike stress test;
  • * Arrhythmia which would prevent adequate cardiac gating, including atrial fibrillation;
  • * Reduced left ventricular systolic function (\<40%);
  • * History of surgical aortic valve replacement or patients who undergo a valve-in-valve TAVR procedures;
  • * Significant non-treated coronary artery disease.

Ages Eligible for Study

18 Years to 105 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University Hospitals Cleveland Medical Center,

Guilherme Attizzani, MD, PRINCIPAL_INVESTIGATOR, UH, Cleveland Medical Center

Sadeer Al-Kindi, MD, PRINCIPAL_INVESTIGATOR, University Hospitals Cleveland Medical Center

Study Record Dates

2025-12-30