Effects of Mouthrinses on the Microbiome of the Oral Cavity and GI Tract

Description

The purpose of this research study is to identify the effects of 2 over-the-counter mouthwashes on bacteria and 3 viruses in the participant's mouth and gut. The participant will be randomly allocated to rinse their mouth twice daily either with Listerine mouthwash, Lumineux Oral Essentials mouthwash, or water. The overall duration of the study will be approximately 180 days and will include approximately 5 visits and 15-30 minutes for each visit with a total of approximately 2.5 hours of your time. Additionally, fecal matter will also be collected in some subjects using a commercial collection kit.

Conditions

Oral Bacterial Infection, Oral Infection, Microbial Colonization, Viral Infection

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Study Overview

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Study Details

Study overview

The purpose of this research study is to identify the effects of 2 over-the-counter mouthwashes on bacteria and 3 viruses in the participant's mouth and gut. The participant will be randomly allocated to rinse their mouth twice daily either with Listerine mouthwash, Lumineux Oral Essentials mouthwash, or water. The overall duration of the study will be approximately 180 days and will include approximately 5 visits and 15-30 minutes for each visit with a total of approximately 2.5 hours of your time. Additionally, fecal matter will also be collected in some subjects using a commercial collection kit.

Effects of Mouthrinses on the Microbiome of the Oral Cavity and GI Tract

Effects of Mouthrinses on the Microbiome of the Oral Cavity and GI Tract

Condition
Oral Bacterial Infection
Intervention / Treatment

-

Contacts and Locations

Irvine

Beckman Laser Institute and Medical Clinic, Irvine, California, United States, 92612

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Eligible men and non-pregnant and non-lactating women of all races age 18-25.
  • * Volunteers must consent to participate in all scheduled exam visits and procedures.
  • * Volunteers must be available for follow up on the telephone.
  • * Healthy gums or gums that bleed when you brush them.
  • * Volunteers unable or unwilling to sign the informed consent form.
  • * Less than 20 teeth (excluding third molars).
  • * Individuals who have taken antibiotics in the previous 3 months.
  • * Presence of any condition, abnormality, or situation at Baseline that in the opinion of the Principal Investigator may preclude the volunteer's ability to comply with study requirements, including completion of the study or the quality of the data.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Irvine,

Petra Wilder-Smith, DDS, PhD, PRINCIPAL_INVESTIGATOR, University of Calfornia Irvine

Study Record Dates

2027-12