Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty

Description

With a rising population of transgender adults and youth, there is a need for more research to meet the needs of this community. Transfemale (MTF) youth (male sex, female gender identity) who begin clinical Gender Affirming Hormone Therapy (GAHT) with estrogen may be at a higher risk for headache since estrogen has been linked to headache in cisgender females (female sex, female gender identity). This research hopes to learn more about headache in MTF youth.

Conditions

Headache, Gender Identity

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Study Overview

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Study Details

Study overview

With a rising population of transgender adults and youth, there is a need for more research to meet the needs of this community. Transfemale (MTF) youth (male sex, female gender identity) who begin clinical Gender Affirming Hormone Therapy (GAHT) with estrogen may be at a higher risk for headache since estrogen has been linked to headache in cisgender females (female sex, female gender identity). This research hopes to learn more about headache in MTF youth.

Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty

Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty

Condition
Headache
Intervention / Treatment

-

Contacts and Locations

Aurora

Children's Hospital Colorado, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Identify as MTF
  • * Age 11-20 years at the time of enrollment
  • * Plan to start estrogen clinically in \< 6 months
  • * Identify as cisgender male
  • * Age 9-20 years at the time of enrollment
  • * No diagnosis of Klinefelter Syndrome (XXY)
  • * Cognitive, or psychiatric impairment resulting in inability to tolerate the study procedures not including depression or anxiety
  • * Known history of stroke, multiple sclerosis, or other serious neurologic condition
  • * MRI-specific exclusion criteria (Weight \> 500 lbs, claustrophobia, metal in body)

Ages Eligible for Study

9 Years to 20 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Colorado, Denver,

Jennifer Hranilovich, MD, PRINCIPAL_INVESTIGATOR, Children's Hospital Colorado

Study Record Dates

2025-06