Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Description

This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.

Conditions

Colorectal Polyp, Colorectal Neoplasms, Colorectal Adenoma, Colorectal Cancer, Digestive System Disease

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Study Overview

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Study Details

Study overview

This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.

Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Condition
Colorectal Polyp
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama Birmingham, Birmingham, Alabama, United States, 35233

Walnut Creek

Kaiser Permanente Northern California, Walnut Creek, California, United States, 94596

Aurora

University of Colorado, Aurora, Colorado, United States, 80045

Lebanon

Dartmouth Health, Lebanon, New Hampshire, United States, 03756

Portland

Kaiser Permanente Northwest, Portland, Oregon, United States, 97232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English or Spanish speaking
  • * Personal history of colorectal polyps
  • * Most recent colonoscopy with ≤2 non-advanced polyps
  • * Currently due or coming due within 12 months for colonoscopy
  • * Able to provide written informed consent
  • * Personal history of colorectal cancer
  • * Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome)
  • * Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
  • * Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps
  • * Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year)
  • * Patients unable to provide written informed consent

Ages Eligible for Study

65 Years to 82 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Dartmouth-Hitchcock Medical Center,

Audrey H Calderwood, MD, MS, PRINCIPAL_INVESTIGATOR, Dartmouth-Hitchcock Medical Center

Theodore R Levin, MD, PRINCIPAL_INVESTIGATOR, Kaiser Permante Northern California

Study Record Dates

2035-12-31