Determining the Role of Social Reward Learning in Social Anhedonia

Description

This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.

Conditions

Psychosis

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Study Overview

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Study Details

Study overview

This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.

Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach

Determining the Role of Social Reward Learning in Social Anhedonia

Condition
Psychosis
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35294

Los Angeles

University of California Los Angeles, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-35 years
  • * A first episode of a psychotic illness that began within the past three years
  • * Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
  • * Taking 2nd generation antipsychotic medications
  • * Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading
  • * Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning
  • * Sufficient fluency in English to comprehend testing procedures
  • * Corrected vision of at least 20/30
  • * No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)
  • * No evidence of moderate or severe alcohol or substance use disorder in the past 3 months
  • * No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury
  • * For females: no current pregnancy
  • * No sedatives or anxiolytics on the day of assessment
  • * No medication change 3 weeks prior to enrollment

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Alabama at Birmingham,

Study Record Dates

2027-11