RECRUITING

Determining the Role of Social Reward Learning in Social Anhedonia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.

Official Title

Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach

Quick Facts

Study Start:2023-06-14
Study Completion:2027-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05617898

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 35 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-35 years
  2. * A first episode of a psychotic illness that began within the past three years
  3. * Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
  4. * Taking 2nd generation antipsychotic medications
  5. * Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading
  6. * Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning
  7. * Sufficient fluency in English to comprehend testing procedures
  8. * Corrected vision of at least 20/30
  1. * No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)
  2. * No evidence of moderate or severe alcohol or substance use disorder in the past 3 months
  3. * No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury
  4. * For females: no current pregnancy
  5. * No sedatives or anxiolytics on the day of assessment
  6. * No medication change 3 weeks prior to enrollment

Contacts and Locations

Study Contact

Junghee Lee, PhD
CONTACT
205-934-8205
jungheelee@uabmc.edu
Andrew Meddaugh, BA
CONTACT
205-934-8203
ajmeddaugh@uabmc.edu

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35294
United States
University of California Los Angeles
Los Angeles, California, 90095
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-06-14
Study Completion Date2027-11

Study Record Updates

Study Start Date2023-06-14
Study Completion Date2027-11

Terms related to this study

Keywords Provided by Researchers

  • social anhedonia, social reward learning, fMRI, sensitivity to reward

Additional Relevant MeSH Terms

  • Psychosis