RECRUITING

Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays? Subjects will complete six months of one of three medication regimens: 1. Saline irrigation followed by azelastine spray and mometasone spray 2. Mometasone saline irrigation 3. Azelastine saline irrigation combined with mometasone saline irrigation.

Official Title

Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis

Quick Facts

Study Start:2022-11-23
Study Completion:2026-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05626621

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy.
  2. * Diagnosis of Chronic Rhinitis.
  1. * The patient has diagnosis(es) other than chronic rhinitis that can account for his/her symptoms (septal deviation, nasal valve collapse, chronic sinusitis).
  2. * Use of oral antihistamines or oral steroids, unless patient undergoes a 4 week washout period.
  3. * Smokers (tobacco, marijuana, vaping, etc.).
  4. * Known or suspected pregnancy, or lactation.
  5. * Other medical conditions that the investigator believed would confound the study.
  6. * Allergy to study drugs.

Contacts and Locations

Study Locations (Sites)

Northshore University HealthSystem
Evanston, Illinois, 60201
United States

Collaborators and Investigators

Sponsor: NorthShore University HealthSystem

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-11-23
Study Completion Date2026-08

Study Record Updates

Study Start Date2022-11-23
Study Completion Date2026-08

Terms related to this study

Keywords Provided by Researchers

  • mometasone
  • azelastine
  • irrigation
  • topical therapy
  • nasal spray
  • chronic rhinitis

Additional Relevant MeSH Terms

  • Chronic Rhinitis