Impact of Dietary Fiber Supplementation on Colonic Mucosal Microbiome

Description

This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.

Conditions

Benign Colorectal Neoplasm, Non-Neoplastic Anal Disorder

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Study Overview

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Study Details

Study overview

This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.

Changes in Colonic Microbiome With Fiber Supplementation

Impact of Dietary Fiber Supplementation on Colonic Mucosal Microbiome

Condition
Benign Colorectal Neoplasm
Intervention / Treatment

-

Contacts and Locations

Portland

OHSU Knight Cancer Institute, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \>= 18 years
  • * Ability to understand and the willingness to sign a written informed consent document
  • * Patients who present with a chief complaint of a benign anorectal pathology including hemorrhoids, anal fissures, and anal fistulas without underlying conditions such as cancer or Crohn's disease or are undergoing a standard of care colonoscopy procedure
  • * Patients with an active malignancy, Crohn's disease, ulcerative colitis, and immunosuppressed patients.
  • * Patients with hereditary colon cancer syndrome including Lynch syndrome or Familial Adenomatous Polyposis (FAP)
  • * Patients with a prior history of total or partial colon resection.
  • * Colorectal pathology such as polyps or cancer

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

OHSU Knight Cancer Institute,

Vassiliki L Tsikitis, M.D., PRINCIPAL_INVESTIGATOR, OHSU Knight Cancer Institute

Study Record Dates

2024-12-31