Targeting the Default Mode Network: A TMS-fMRI Study

Description

In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this would lead to a personalized approach to rTMS treatment of PTSD based on brain imaging that can be used in a future clinical trial. Participants will be asked to complete psychological testing and questionnaires as well as an initial MRI and two separate TMS-fMRI sessions. Total participation time across all visits is estimated to be five to six hours. Research participation will take place at VA Palo Alto as well as at Stanford University.

Conditions

Post Traumatic Stress Disorder, PTSD

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Study Overview

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Study Details

Study overview

In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this would lead to a personalized approach to rTMS treatment of PTSD based on brain imaging that can be used in a future clinical trial. Participants will be asked to complete psychological testing and questionnaires as well as an initial MRI and two separate TMS-fMRI sessions. Total participation time across all visits is estimated to be five to six hours. Research participation will take place at VA Palo Alto as well as at Stanford University.

Targeting the Default Mode Network: A TMS-fMRI Study

Targeting the Default Mode Network: A TMS-fMRI Study

Condition
Post Traumatic Stress Disorder
Intervention / Treatment

-

Contacts and Locations

Palo Alto

VA Palo Alto, Palo Alto, California, United States, 94304

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Between 18 and 55 years of age
  • * Ability to maintain a Motor Threshold (MT) with single pulse TMS
  • * Ability to safely and comfortably undergo an MRI and TMS
  • * Able to read, verbalize, understand, and voluntarily sign the Informed Consent Form prior to participating in any study-specific procedures or assessments.
  • * PTSD diagnosis according to the DSM 5, as determined by the Clinician administered PTSD scale (CAPS-5) criteria.
  • * Commitment to maintaining a stable medication regimen between the two fMRI sessions
  • * Inability to safely and comfortably undergo an MRI. MRI safety will be determined by the center where MRI's are collected.
  • * Inability to safely and comfortably undergo TMS. TMS exclusions include any history or condition that puts patients at risk.
  • * Significant dementia as determined by the Montreal Cognitive Assessments (MoCA)
  • * Common comorbid disorders of Veterans are allowed, but PTSD must be a primary diagnosis causing significant impairment that could not be accounted for by another diagnosis. Medical or mental health conditions that interact with or confound interpretation of PTSD symptoms and anxiety would be exclusionary.
  • * Being in urgent need of care that would make participation impossible
  • * Currently taking medications that increase the risk of seizure or influence hemodynamic response
  • * Presence of any other condition that has the potential to prevent study completion and/or have a confounding effect on the interpretation of results.

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Allyson Rosen,

Allyson C Rosen, Ph.D., PRINCIPAL_INVESTIGATOR, PAVIR/Palo Alto VAHCS/Stanford University

Study Record Dates

2025-01-31