Improving Exercise Rehabilitation Efficacy Outcomes Veterans Peripheral Artery Disease

Description

Physical activity is the most beneficial and cost-effective treatment for Veterans with PAD, however, issues with oxygen delivery and utilization dramatically impair exercise compliance. The cause of these oxygen delivery and utilization impairments is likely increased oxidative stress and inflammation. The proposed project will comprehensively examine the novel strategy of Nuclear Factor Erythroid-2-like 2 (Nrf2) activation using PB125, aimed at diminishing oxidative stress and inflammation, and thereby lessening the negative impacts of the disease. This therapeutic will be evaluated in isolation and in combination with exercise rehabilitation to determine if there is a complimentary benefit. The ultimate goal is to provide insight into a potential novel therapeutic treatment for this disease, therefore, improving exercise tolerance and quality of life in this growing population.

Conditions

Peripheral Artery Disease (D058729), Oxidative Stress (D018384), Inflammation (D007249)

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Study Overview

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Study Details

Study overview

Physical activity is the most beneficial and cost-effective treatment for Veterans with PAD, however, issues with oxygen delivery and utilization dramatically impair exercise compliance. The cause of these oxygen delivery and utilization impairments is likely increased oxidative stress and inflammation. The proposed project will comprehensively examine the novel strategy of Nuclear Factor Erythroid-2-like 2 (Nrf2) activation using PB125, aimed at diminishing oxidative stress and inflammation, and thereby lessening the negative impacts of the disease. This therapeutic will be evaluated in isolation and in combination with exercise rehabilitation to determine if there is a complimentary benefit. The ultimate goal is to provide insight into a potential novel therapeutic treatment for this disease, therefore, improving exercise tolerance and quality of life in this growing population.

Improving Exercise Rehabilitation Efficacy and Outcomes in Veterans With Peripheral Artery Disease: Targeting Oxidative Stress and Inflammation

Improving Exercise Rehabilitation Efficacy Outcomes Veterans Peripheral Artery Disease

Condition
Peripheral Artery Disease (D058729)
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

University of Utah Dept of Vascular Surgery, Salt Lake City, Utah, United States, 84132

Salt Lake City

VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah, United States, 84148-0001

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 40 and older with clinically diagnosed femoropopliteal PAD (ankle-brachial index \< 0.9)
  • * Must understand the study requirements and be willing and able to sign an informed consent document
  • * Patients with mild cognitive impairment (i.e., montreal cognitive assessment (MOCA) \<26) will be included but must have a responsible caregiver or spouse present during the informed consent
  • * Women that are not pregnant, breastfeeding, or likely to become pregnant within the next 6 months
  • * Patients with a bleeding disorder that would contraindicate the performance of a muscle biopsy, such as a history of clinically significant bleeding diathesis (i.e., Hemophilia A or B, Von Willebrand's Disease, or congenital Factor VII deficiency)
  • * Patients with a complex atherosclerotic lesion such that withholding medication creates disproportionate risk
  • * Women currently taking hormone replacement therapy
  • * Any other condition or event considered exclusionary by the PI and faculty physician

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Jesse Craig, MBA, PRINCIPAL_INVESTIGATOR, VA Salt Lake City Health Care System, Salt Lake City, UT

Study Record Dates

2028-06-01