Lifestyle Intervention for Improving Insulin Resistance and Concern for Health

Description

The primary objective of this study is to test the effect of a diet and exercise program in older adults with insulin resistance and a motivation disorder known as apathy. The main questions the study aims to answer are: 1. Does the diet and exercise program improve insulin resistance and apathy? 2. Does the addition of soybean to the diet enhance the effect? Participants will be given all meals for 12 weeks and will exercise under supervision. They will undergo a test of insulin sensitivity and complete questionnaires. Researchers will compare the groups given: 1. A diet to moderate the blood glucose response that contains soybean; and 2. A diet to moderate the blood glucose response that does not contain soybean.

Conditions

Insulin Sensitivity, Apathy

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Study Overview

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Study Details

Study overview

The primary objective of this study is to test the effect of a diet and exercise program in older adults with insulin resistance and a motivation disorder known as apathy. The main questions the study aims to answer are: 1. Does the diet and exercise program improve insulin resistance and apathy? 2. Does the addition of soybean to the diet enhance the effect? Participants will be given all meals for 12 weeks and will exercise under supervision. They will undergo a test of insulin sensitivity and complete questionnaires. Researchers will compare the groups given: 1. A diet to moderate the blood glucose response that contains soybean; and 2. A diet to moderate the blood glucose response that does not contain soybean.

Lifestyle Intervention for Improving Metabolic and Motivational Outcomes

Lifestyle Intervention for Improving Insulin Resistance and Concern for Health

Condition
Insulin Sensitivity
Intervention / Treatment

-

Contacts and Locations

Baton Rouge

Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States, 70808

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Body mass index (BMI) greater than or equal to 30kg/m2
  • * Mini-Mental State Examination (MMSE) \> 25
  • * Geriatric Depression Scale-15 (GDS-15) \< 6
  • * Apathy Evaluation Scale - score \> 30 or GDS-15 Apathy subscale - score ≥ 2
  • * Homeostatic model assessment of insulin resistance (HOMA-IR) ≥ 3
  • * Sedentary: \< 90 minutes of moderate to vigorous physical activity/week.
  • * Subjects with a diagnosis of Type 2 diabetes received more than five years ago.
  • * Participants who have type 1 diabetes
  • * Participants being treated with prescription or over the counter medications that have a significant effect on insulin resistance, obesity, high density lipoprotein cholesterol, triglycerides, metabolic rate and those that significantly increase body weight.
  • * Participants who are on concomitant therapy with glucocorticoids.
  • * Participants with evidence and/or history (within the preceding 6 months) of significant gastrointestinal dysfunction.
  • * Participants that have had a fluctuation in body weight \>5% in the preceding 2 months.
  • * Any other conditions that may impede testing of the study hypothesis.

Ages Eligible for Study

50 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Pennington Biomedical Research Center,

Candida J Rebello, PRINCIPAL_INVESTIGATOR, Pennington Biomedical Research Center

Study Record Dates

2025-05