Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

Eligibility Criteria

• * Healthy on the basis of medical history and limited physical examination-
• * Heart rate \< 105 beats per minute (BPM)\*.
• * Systolic Blood Pressure \< 160 and \> 90\*.
• * Diastolic Blood Pressure \< 100 and \> 50\*.
• * \*considered out of range if both machine and manual readings are above/below these thresholds.
• * Body Mass Index \<= 38.0.
• * Current regular user of electronic cigarettes (EC)
• * EC device use at least 15 or more days in the past 30 days (with e- liquid \>= 3mg/ml)
• * No restriction on flavor or type of e-cigarette used
• * Saliva cotinine \>= 50 ng/ml and/or NicAlert = 6
• * Age \>= 21 years old \<= 70 years old
• * Willingness to abstain from drug use for the duration of the study
• * The following unstable medical conditions:
• * Heart disease
• * Seizures
• * Cancer
• * Thyroid disease (okay if controlled with medication)
• * Diabetes
• * Hepatitis B or C or Liver disease
• * Glaucoma
• * Kidney disease or urinary retention
• * History of stroke
• * An ulcer in the past year
• * Active use of an inhaler for Asthma or chronic obstructive pulmonary disease (COPD)
• * Medications
• * Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
• * Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
• * Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
• * Any stimulant medications (example: Adderall) generally given for attention deficit hyperactivity disorder (ADHD) treatment.
• * Other/Misc. Health Conditions
• * Oral thrush
• * Fainting (within the last 30 days)
• * Other "life threatening illnesses" as per principal investigator and/or study physician's discretion
• * Pregnancy
• * Pregnancy (self-reported and urine pregnancy test)
• * Breastfeeding (determined by self-report)
• * Women of childbearing potential must be using an acceptable method of contraception
• * Concurrent participation in another clinical trial.
• * Inability to read and write in English
• * Planning to quit smoking or vaping within the next 60 days
• * A known propylene glycol/vegetable glycerin allergy
• * Uncomfortable with getting blood drawn
• * Recent onset or change (worsening) in cough, fever and/or abdominal symptoms (vomiting or pain) in the past two weeks