Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

Description

To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.

Conditions

Alzheimer's Disease

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Study Overview

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Study Details

Study overview

To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.

Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

Condition
Alzheimer's Disease
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114-2696

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Enrolled in MPC study (Protocol 850160 at UPenn; Protocol 2022P002447 at MGH).
  • 2. Reliable study partner to accompany participant to the PET/CT scan
  • 3. A brain MRI must be performed within 6 months prior to their study AV-1451 TAU PET/CT scan date and be deemed of adequate quality that the scan may be used for study analysis, including 3T high-resolution imaging of medial temporal lobe structures.
  • 1. Have any medical or psychiatric conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.
  • 2. Have evidence of structural abnormalities such as major stroke or mass on MRI that is likely to interfere with analysis of the PET/CT scan.
  • 3. Inability to tolerate or contraindication to imaging procedures in the opinion of an investigator or treating physician.
  • 4. Have a history of significant ongoing alcohol or substance abuse based on self- report.
  • 5. Female participants of child-bearing age will not be able to participate in this study, determined by self-report.

Ages Eligible for Study

18 Years to 120 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

David A. Wolk, PRINCIPAL_INVESTIGATOR, University of Pennsylvania Department of Neurology at the Perelman School of Medicine

Sandhitsu R. Das, PRINCIPAL_INVESTIGATOR, University of Pennsylvania Department of Neurology at the Perelman School of Medicine

Study Record Dates

2029-12