Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation

Description

The purpose of the study is to explore options for preventing and reducing symptoms of radiation esophagitis (RE). The researchers will also look what symptoms participants experience, and whether there are differences in weight loss in participants.

Conditions

Radiation Esophagitis

Study Overview

Study Details

Study overview

The purpose of the study is to explore options for preventing and reducing symptoms of radiation esophagitis (RE). The researchers will also look what symptoms participants experience, and whether there are differences in weight loss in participants.

Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation

Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation

Condition
Radiation Esophagitis
Intervention / Treatment

-

Contacts and Locations

Basking Ridge

Memorial Sloan Kettering Cancer Center Basking Ridge (All Protocol Activities), Basking Ridge, New Jersey, United States, 07920

Middletown

Memorial Sloan Kettering Monmouth (All Protocol Activities), Middletown, New Jersey, United States, 07748

Montvale

Memorial Sloan Kettering Bergen (All Protocol Activities), Montvale, New Jersey, United States, 07645

Commack

Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities ), Commack, New York, United States, 11725

Harrison

Memorial Sloan Kettering Westchester (All Protocol Activities), Harrison, New York, United States, 10604

New York

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States, 10065

Uniondale

Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale, New York, United States, 11553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients being treated with thoracic irradiation with high-risk esophageal dose as determined below:
  • * V50 ≥ 15% (25-35 once daily fractions) or 40 twice-daily \[BID\] fractions)
  • * V40 ≥ 15% (15-24 once daily fractions or 30 twice-daily \[BID\] fractions)
  • * V30 ≥ 15% (10-14 once daily fractions)
  • * Age 18 years of age or older.
  • * Known inability to take Sucralfate (tablet and/or suspension form), per physician discretion
  • * PEG tube
  • * Actively taking any opioid pain medications prior to radiation therapy
  • * History of an opioid use disorder

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Jacob Shin, MD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2025-12