NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits

Description

Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23

Conditions

Working Memory

Talk to us

Study Overview

On this page

Study Details

Study overview

Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23

NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits

NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits

Condition
Working Memory
Intervention / Treatment

-

Contacts and Locations

East Providence

E. P. Bradley Hospital, East Providence, Rhode Island, United States, 02915

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Intracranial pathology from a known genetic disorder (e.g., NF1, tuberous sclerosis) or from acquired neurologic disease (e.g. stroke, tumor), cerebral palsy, history of severe head injury, or significant dysmorphology
  • 2. History of fainting spells of unknown or undetermined etiology that might constitute seizures
  • 3. History of seizures, diagnosis of epilepsy, or immediate (1st degree relative) family history epilepsy
  • 4. Any progressive (e.g., neurodegenerative) neurological disorder
  • 5. Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
  • 6. Contraindicated metal implants in the head, brain or spinal cord (excluding dental implants, braces or fillings)
  • 7. Non-removable makeup or piercings
  • 8. Pacemaker
  • 9. Implanted medication pump
  • 10. Vagal nerve stimulator
  • 11. Deep brain stimulator
  • 12. TENS unit (unless removed completely for the study)
  • 13. Ventriculo-peritoneal shunt
  • 14. Signs of increased intracranial pressure
  • 15. Intracranial lesion (including incidental finding on MRI)
  • 16. History of head injury resulting in prolonged loss of consciousness
  • 17. Substance abuse or dependence within past six months (i.e., DSM-5 substance use disorder criteria)
  • 18. Chronic treatment with prescription medications that decrease cortical seizure threshold, not including psychostimulant medication if deemed to be medically safe as part of the medical review process.
  • 19. Active psychosis or mania
  • 20. Current suicidal intent
  • 21. Current pregnancy
  • 22. Significant visual, hearing or speech impairment
  • 23. Current wards of the state

Ages Eligible for Study

12 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Bradley Hospital,

Study Record Dates

2026-12-01