State Representation in Early Psychosis - Project 4

Description

The purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis. State Representation is our ability to process information about our surroundings. The investigators will complete a clinical trial examining two paradigms of cognitive training.

Conditions

Psychosis, Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Schizoaffective Disorder

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Study Overview

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Study Details

Study overview

The purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis. State Representation is our ability to process information about our surroundings. The investigators will complete a clinical trial examining two paradigms of cognitive training.

State Representation in Early Psychosis - Project 4

State Representation in Early Psychosis - Project 4

Condition
Psychosis
Intervention / Treatment

-

Contacts and Locations

Minneapolis

University of Minnesota, Minneapolis, Minnesota, United States, 55454

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English proficiency, as determined by staff observation and participant self-report
  • * Estimated IQ at or above 70, as estimated by the cognitive assessments
  • * Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis; participants aged 36-45 must have onset of psychosis within the past 5 years
  • * Achieved clinical stability, defined as outpatient status for at least one month prior to study participation
  • * Unable or unwilling to provide informed consent
  • * The participant is unable to demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in the research study
  • * Participant is pregnant
  • * Participant is illiterate
  • * Cannot pass the CMRR Subject Safety Screen due to MRI contraindications
  • * Presence of a major neurological disorder
  • * Previous clinically significant head injury or prolonged unconsciousness, as determined by the PI/Co-Is
  • * Meets criteria for substance or alcohol dependence within 3 months of enrollment
  • * The presence of any major medical condition that, in the opinion of the PI/Co-Is, would impede participation in the study or would put the participant at additional risk by participating
  • * Presence of severe alcohol or substance abuse
  • * Has participated in significant formal cognitive training programs, as determined by the PI/Co-Is
  • * Meets criteria for clinical risk of suicidal behavior, as defined by:
  • * A suicide attempt within 6 months of enrollment
  • * Active suicidal ideation at screening or baseline, as indicated by the C-SSRS
  • * Previous intent to act on suicidal ideation with a specific plan and/or preparatory acts within 6 months of enrollment, as indicated by the C-SSRS
  • * Meets DSM-5 criteria for psychotic, bipolar, or autism spectrum disorder
  • * Has a family history (1st degree relative) of psychotic, bipolar, or autism spectrum disorder

Ages Eligible for Study

15 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Minnesota,

Sophia Vinogradov, MD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Angus MacDonald III, Ph.D., PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

2025-03-31