The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.
Nasal Polyps, Aspirin-exacerbated Respiratory Disease
The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.
Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
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Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
Yes
Brigham and Women's Hospital,
Tanya Laidlaw, PRINCIPAL_INVESTIGATOR, Brigham and Women's Hospital
2023-12-01