RECRUITING

PRP for Glenohumeral Osteoarthritis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The glenohumeral joint is the third most common large joint to be affected by OA. Conservative treatments include physical activity, corticosteroid injections, and medications. PRP is an emerging treatment that has shown efficacy in different musculoskeletal conditions. The use of PRP for glenohumeral OA has been described sparingly in the literature but has shown efficacy in a couple studies and case reports. However, all of the previous studies investigating PRP for glenohumeral OA have focused on low-dose PRP preparations (\~3X), and none have compared PRP treatment to saline treatment. This study aims to compare outcomes following single injections of low-dose PRP, high-dose PRP, or saline in patients with glenohumeral osteoarthritis.

Official Title

Outcomes Following Single Injections of Low-dose Platelet-rich Plasma (PRP), High-dose PRP, or Saline in Patients With Glenohumeral OA: a Randomized Controlled Trial

Quick Facts

Study Start:2023-05-02
Study Completion:2025-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05675527

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-100 years old
  2. * Average NRS pain greater than or equal to 5/10 as a direct result of glenohumeral osteoarthritis (any severity: mild, moderate, or severe) and/or chondral lesion or loss
  3. * At least 3 months of pain after onset of symptoms that has failed conservative treatments, including physical therapy
  4. * MRI of the affected joint
  5. * Transient relief of symptoms after a diagnostic intra-articular injection into the joint
  6. * Email address or network access
  1. * Inability to hold non-steroidal anti-inflammatory drugs for 2 weeks prior and 1 month after the injection
  2. * Prior platelet-rich plasma injection
  3. * Steroid injection within 3 months of the initial injection
  4. * Hyaluronic acid within 6 months of the initial injection
  5. * Involved in workers' compensation or active litigation involving the affected joint
  6. * History of Plavix use
  7. * Known uncontrolled systemic illness (uncontrolled diabetes, HIV, vasculitis, autoimmune/autoinflammatory disease)
  8. * Presence of acute fractures or gross mechanical deformities
  9. * Concurrent "uncontrolled" cervical disorders

Contacts and Locations

Study Contact

Jonathan Kirschner, MD
CONTACT
646-714-6327
kirschnerj@hss.edu
Jennifer Cheng
CONTACT
646-714-6870
chengj@hss.edu

Study Locations (Sites)

Hospital for Special Surgery
New York, New York, 10021
United States

Collaborators and Investigators

Sponsor: Hospital for Special Surgery, New York

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-02
Study Completion Date2025-09-01

Study Record Updates

Study Start Date2023-05-02
Study Completion Date2025-09-01

Terms related to this study

Additional Relevant MeSH Terms

  • Shoulder Osteoarthritis