Confirmation of Diet as a Treatment for Gulf War Illness

Description

This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention. The main objectives of this study are: 1) to confirm previous findings of treatment response to the diet in a larger and more diverse group; 2) to examine how changes in the nervous system may be the reason for improvement; and 3) to identify markers which change in the blood after one month on the diet. Participants will have baseline measures collected and then will be randomized into the intervention or wait-listed control group, which they will follow for one month before being reassessed.

Conditions

Gulf War Syndrome, Gulf War Illness

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Study Overview

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Study Details

Study overview

This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention. The main objectives of this study are: 1) to confirm previous findings of treatment response to the diet in a larger and more diverse group; 2) to examine how changes in the nervous system may be the reason for improvement; and 3) to identify markers which change in the blood after one month on the diet. Participants will have baseline measures collected and then will be randomized into the intervention or wait-listed control group, which they will follow for one month before being reassessed.

Confirmation of Diet as a Treatment for Gulf War Illness

Confirmation of Diet as a Treatment for Gulf War Illness

Condition
Gulf War Syndrome
Intervention / Treatment

-

Contacts and Locations

Washington

American University, Washington, District of Columbia, United States, 20016

Fort Lauderdale

Nova Southeastern University, Fort Lauderdale, Florida, United States, 33314

Boston

Boston University, Boston, Massachusetts, United States, 02118

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Males and Females of all races and ethnicities who are ≤75 yrs of age
  • * Served in the 1990-1991 Persian Gulf War
  • * Fulfill both Center for Disease Control (CDC) and Kansas definitions of Gulf War Illness
  • * Stable medication regimen for ≥1 month and willing to keep medications and supplements stable throughout study participation
  • * Recent substance use disorder (past year)
  • * Unwilling to stop using alcohol, tobacco (including vaping) and/or marijuana; or unwilling to change diet
  • * Diagnosed seizure disorder or severe asthma requiring past hospitalization
  • * Currently taking medication which affects glutamatergic or GABAergic neurotransmission (but can work with their physician to wean off of these medications prior to participating)

Ages Eligible for Study

50 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

American University,

Kathleen F Holton, PhD, MPH, PRINCIPAL_INVESTIGATOR, American University

Study Record Dates

2025-12-30