Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

Description

This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.

Conditions

CADASIL

Study Overview

Study Details

Study overview

This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.

Unraveling the Early Phases of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

Condition
CADASIL
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California, Los Angeles, California, United States, 90095

San Francisco

University of California, San Francisco, California, United States, 94143

Denver

University of Colorado, Denver, Colorado, United States, 80204

Atlanta

Georgia State University Research Foundation, Atlanta, Georgia, United States, 30303

Chicago

Loyola University, Chicago, Illinois, United States, 60660

New York City

Columbia University, New York City, New York, United States, 10027

Portland

Oregon Health & Science University, Portland, Oregon, United States, 97239

Providence

Brown University, Providence, Rhode Island, United States, 02912

Houston

University of Texas Health Science Center, Houston, Texas, United States, 77030

San Antonio

University of Texas, San Antonio, Texas, United States, 78249

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. History of severe learning disability, intellectual disability, or other neurological disease or event not attributable to CADASIL
  • 2. History of serious alcohol or drug abuse within the past year
  • 3. Unwilling to undergo NOTCH3 genetic testing if there is no test on file

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Wisconsin, Madison,

Jane S Paulsen, PhD, PRINCIPAL_INVESTIGATOR, University of Wisconsin, Madison

Michael D Geschwind, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-01