OMAR Opioid Use Disorder

Description

The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid receptor 1 (CB1R) availability.

Conditions

Healthy Control, Opioid Use Disorder

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Study Overview

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Study Details

Study overview

The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid receptor 1 (CB1R) availability.

Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder

OMAR Opioid Use Disorder

Condition
Healthy Control
Intervention / Treatment

-

Contacts and Locations

New Haven

Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut, United States, 06519

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Able to provide informed consent
  • * Male and female 18 years and older
  • * DSM-5 diagnosis of opioid use disorder (for OUD group)
  • * Physically healthy i.e., no clinically unstable medical conditions
  • * Written informed consent and have capacity to consent and comply with study procedures
  • * Current neuro-psychiatric illness or severe systemic disease (opioid use disorder is permitted in the OUD group).
  • * Presence of ferromagnetic metal in the body or heart pacemaker
  • * Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits
  • * Are claustrophobic

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Anahita Bassir Nia, MD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2025-12-15