Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients

Description

The goal of this clinical trial is to test the effectiveness of an integrated infectious disease/substance use disorder (SUD) clinical team intervention approach in patients hospitalized with severe injection-related infections (SIRI) who use drugs. The main question this study aims to answer is whether this intervention approach will be associated with lower mortality and fewer hospital readmissions. Participants will participate in the integrated SUD/ID care team intervention (SIRI Team). Researchers will compare this intervention to treatment as usual (TUA) to see if there are any differences in health outcomes.

Conditions

Injection Site Infection, Substance Use Disorders

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to test the effectiveness of an integrated infectious disease/substance use disorder (SUD) clinical team intervention approach in patients hospitalized with severe injection-related infections (SIRI) who use drugs. The main question this study aims to answer is whether this intervention approach will be associated with lower mortality and fewer hospital readmissions. Participants will participate in the integrated SUD/ID care team intervention (SIRI Team). Researchers will compare this intervention to treatment as usual (TUA) to see if there are any differences in health outcomes.

Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients

Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients

Condition
Injection Site Infection
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35294

Miami

University of Miami - Jackson Memorial Hospital, Miami, Florida, United States, 33136

Tampa

Tampa General Hospital, Tampa, Florida, United States, 33601

Albuquerque

University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States, 87106

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Salt Lake City

University of Utah Hospital, Salt Lake City, Utah, United States, 84132

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be admitted to a participating hospital at the time of randomization
  • * Be 18 years of age or older
  • * Currently be experiencing a severe injection-related infection/SIRI or suspected SIRI
  • * Have an indication of injecting drugs in the prior year
  • * Provide informed consent
  • * Ability to communicate in English
  • * Provide sufficient locator information
  • * Sign a HIPAA form and/or EHR release to facilitate record abstraction
  • * Report being willing to return for follow-up visits
  • * have significant cognitive or developmental impairment to the extent that they are unable to provide informed consent
  • * (or their legal guardian/representative) are unable or unwilling to give written informed consent
  • * are currently in jail, prison or other overnight facility as required by court of law or have pending legal action that could prevent participation in study activities
  • * are terminated via site principal investigator decision with agreement from one of the study lead investigators.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Columbia University,

Lisa R Metsch, PhD, PRINCIPAL_INVESTIGATOR, Columbia University

David P Serota, MD, MSc, PRINCIPAL_INVESTIGATOR, University of Miami

Daniel J Feaster, PhD, PRINCIPAL_INVESTIGATOR, University of Miami

Carlos del Rio, MD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2026-02-28