Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * Self-report of systolic blood pressure 125-159 mmHg
- * Measured seated systolic blood pressure 130-159 mmHg at screening visit
- * Body mass index less than 40 kg/m2
- * Total magnesium intake from supplements of no more than 100 mg/day
- * Willing to maintain current diet and supplement use patterns during the 12-week intervention period
- * Measured seated diastolic blood pressure 100 mmHg or greater at screening visit
- * Antacid or laxative use 4 times/week or more within the past 3 months
- * History of cardiovascular disease (myocardial infarction, stroke, revascularization \[coronary artery bypass graft or percutaneous transluminal coronary angioplasty\], or angina pectoris)
- * History of invasive cancer diagnosed within the last 5 years (non-melanoma skin cancer permitted)
- * History of type 1 or 2 diabetes
- * History of renal disease
- * History of kidney failure
- * History of dialysis
- * History of pancreatitis
- * History of inflammatory bowel disease
- * History of hypermagnesemia
- * Women who are pregnant, nursing, or intend to become pregnant during the period of treatment
- * Plan to relocate out of Boston area within the next year
- * Unwillingness and/or inability to swallow 4 pills per day
- * Inability to provide written informed consent
Ages Eligible for Study
30 Years to 74 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
Yes