Micro and Macro Circulation in Sepsis

Description

Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future resuscitation trials. We will serially evaluate microhemodynamics (MiH) and macro hemodynamics (maH) and the perfused boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated circulating biomarker of eGC integrity.

Conditions

Sepsis, Septic Shock

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Study Overview

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Study Details

Study overview

Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future resuscitation trials. We will serially evaluate microhemodynamics (MiH) and macro hemodynamics (maH) and the perfused boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated circulating biomarker of eGC integrity.

Clinical Utility of Longitudinal Measurement of Hemodynamic Incoherence and Endothelial

Micro and Macro Circulation in Sepsis

Condition
Sepsis
Intervention / Treatment

-

Contacts and Locations

Denver

Denver Health Medical Center, Denver, Colorado, United States, 80204

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Greater than or equal to 18 years of age
  • 2. Diagnosed with sepsis or septic shock
  • 3. Require admission to the Hospital
  • 1. Greater than or equal to 18 years of age
  • 2. Undergoing elective surgery requiring intubation and general anesthesia
  • 1. Less than 18 years old
  • 2. Chronic Kidney disease on dialysis
  • 3. Currently pregnant
  • 4. Incarcerated persons
  • 1. Less than 18 years old
  • 2. History of Chronic Kidney disease on dialysis, uncontrolled diabetes, cirrhosis, heart failure, or nephritic or nephrotic syndromes.
  • 3. Currently pregnant
  • 4. Incarcerated persons

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Denver Health and Hospital Authority,

Study Record Dates

2024-12-31