Barotrauma in Hyperbaric Oxygen Therapy

Description

The purpose of this research is to study whether the use of pseudoephedrine can help prevent middle ear trauma during HBOT. Pseudoephedrine is an approved drug that is used for temporary relief of nasal or sinus pain and pressure.

Conditions

Barotrauma

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Study Overview

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Study Details

Study overview

The purpose of this research is to study whether the use of pseudoephedrine can help prevent middle ear trauma during HBOT. Pseudoephedrine is an approved drug that is used for temporary relief of nasal or sinus pain and pressure.

Pseudoephedrine Prophylaxis for Prevention of Middle Ear Barotrauma in Hyperbaric Oxygen Therapy

Barotrauma in Hyperbaric Oxygen Therapy

Condition
Barotrauma
Intervention / Treatment

-

Contacts and Locations

Walnut Creek

John Muir Health, Walnut Creek, California, United States, 94598

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * New patient requiring HBOT (either inpatient or outpatient)
  • * Age greater than or equal to 18 years and less than 80 years
  • * Fluent in English
  • * Full decision capacity
  • * Able and medically cleared to swallow a pill
  • * Enrollment would delay hyperbaric therapy more than 30 minutes in patients with emergent indications (example: Central Retinal Arterial Occlusion, Carbon Monoxide, Air Gas Embolism)
  • * Contraindication to pseudoephedrine (monoamine oxidase inhibitors (MAOI) use, pregnancy, glaucoma, heart disease, allergy to drug class)
  • * Systolic Blood Pressure \>160
  • * Diastolic Blood Pressure \> 90
  • * Heart Rate \>100
  • * Decongestant/antihistamine/pseudoephedrine/nasal steroid/oxymetazoline use within 12 hours.
  • * Prisoner
  • * Intubated
  • * Unable to swallow oral medications

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

John Muir Health,

Jacinta Showers, RN, PRINCIPAL_INVESTIGATOR, John Muir Health

Study Record Dates

2026-07