MRI and Biomarkers for Lung Nodules Detected During Lung Cancer Screening

Description

The primary objective of this pilot observational study is to evaluate the accrual and retention rate of a study population from a centralized lung cancer screening program to support MRI and blood-based biomarker research for lung cancer screening.

Conditions

Lung Cancer

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Study Overview

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Study Details

Study overview

The primary objective of this pilot observational study is to evaluate the accrual and retention rate of a study population from a centralized lung cancer screening program to support MRI and blood-based biomarker research for lung cancer screening.

A Pilot Study Evaluating the Feasibility of Novel MRI Sequences and Blood-Based Biomarkers for Discriminating Nodules Found During Lung Cancer Screening

MRI and Biomarkers for Lung Nodules Detected During Lung Cancer Screening

Condition
Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ability to read and understand informed consent
  • * Male or female adults who are at high risk for lung cancer and are enrolled in the centralized lung cancer screening program: Based on USPSTF guidelines: Age 50-80 with 20 or greater pack-year smoking story who continue to smoke or quit within the past 15 years without sign or symptoms of lung cancer. Or based on National Comprehensive Cancer Network (NCCN) guidelines but do not meet the USPSTF guidelines, age 50-unlimited
  • * Found to have one or more lung nodules that is 6mm or greater on screening LDCT
  • * Persons with an active diagnosis of cancer
  • * Persons with active signs or symptoms of lung cancer
  • * Persons with mechanically, magnetically, or electrically activated implants, such as cardiac pacemakers, neurostimulators, and infusion pumps.
  • * Persons with ferromagnetic implants and ferromagnetic foreign bodies, such as intracranial aneurysm clips, shrapnel and intraocular metal chips as these could become dislodged.
  • * Persons who are pregnant, nursing, are implanted with intrauterine devices (IUD's) that are not MR-compatible
  • * Persons unable to tolerate MRI imaging secondary to an inability to lie supine or severe claustrophobia.
  • * Persons who are non-compliant with visit instructions, including inability to lie still, hold breath or follow procedure instructions

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Cedars-Sinai Medical Center,

Sara Ghandehari, MD, PRINCIPAL_INVESTIGATOR, Cedars-Sinai

Study Record Dates

2026-08-27