RECRUITING

Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild/moderate joint degenerative changes will be potential study subjects. Blood flow around joints will be evaluated using perfusion magnetic resonance imaging (MRI). Participants with demonstrably abnormal blood flow around their painful joint will be eligible for enrollment in a pilot study of joint embolization to treat their pain. Participants who choose to not undergo treatment will be re-assessed with MRI after one year to characterize the natural history of joint neovascularity and its relationship to pain.

Official Title

Perfusion MRI-targeted Joint Embolization to Diagnose and Treat Neovascularity Associated with Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee: a Prospective Cohort Study

Quick Facts

Study Start:2023-07-15
Study Completion:2026-08-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05700682

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:25 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Eric Bultman, MD, PhD
CONTACT
560-493-5000
eric.bultman1@va.gov
Sirish Kishore, MD
CONTACT
650-493-5000
sirish.kishore@va.gov

Principal Investigator

Sirish Kishore, MD
PRINCIPAL_INVESTIGATOR
VA Palo Alto Health Care System

Study Locations (Sites)

VA Palo Alto Healthcare System
Palo Alto, California, 94304
United States

Collaborators and Investigators

Sponsor: Palo Alto Veterans Institute for Research

  • Sirish Kishore, MD, PRINCIPAL_INVESTIGATOR, VA Palo Alto Health Care System

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-15
Study Completion Date2026-08-01

Study Record Updates

Study Start Date2023-07-15
Study Completion Date2026-08-01

Terms related to this study

Keywords Provided by Researchers

  • joint
  • embolization
  • neovascularity
  • pain
  • knee
  • hip
  • shoulder

Additional Relevant MeSH Terms

  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Osteo Arthritis Shoulders
  • Synovitis of Knee
  • Synovitis/Tenosynovitis - Hip
  • Synovitis
  • Pain, Chronic