Rehabilitation of Airway Protection in Parkinson's Disease

Description

Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD. Despite this, a large number of patients with PD do not access specialized services to address these critical deficits. The investigators will examine the comparative effectiveness of a novel treatment paradigm delivered in-person versus via telehealth in persons with PD, as well as the role of patient burden and treatment adherence on outcomes; thus, the proposed research is relevant to public health and in line with NIH's mission to identify novel, efficacious, and accessible rehabilitation strategies for short- and long-term improvement of dysfunctional airway protection in PD.

Conditions

Parkinson Disease, Dysphagia

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Study Overview

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Study Details

Study overview

Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD. Despite this, a large number of patients with PD do not access specialized services to address these critical deficits. The investigators will examine the comparative effectiveness of a novel treatment paradigm delivered in-person versus via telehealth in persons with PD, as well as the role of patient burden and treatment adherence on outcomes; thus, the proposed research is relevant to public health and in line with NIH's mission to identify novel, efficacious, and accessible rehabilitation strategies for short- and long-term improvement of dysfunctional airway protection in PD.

Rehabilitation of Airway Protection in Parkinson's Disease: Comparing In-person and Telehealth Service Delivery Models

Rehabilitation of Airway Protection in Parkinson's Disease

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

West Lafayette

Purdue University, West Lafayette, Indiana, United States, 47907

New York

Teachers College, Columbia University, New York, New York, United States, 10027

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosed with PD (Hoehn and Yahr Stages II-IV)126,127 confirmed by a Movement Disorders fellowship trained neurologist having reviewed the video recorded Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) assessment for each participant and using strict UK brain bank criteria
  • * airway protective deficits as defined as a minimum of penetration of thin liquids (penetration-aspiration score\>3) as determined by instrumental swallowing assessment and/or dystussia as determined by voluntary cough assessment (PEFR ≤4.1 L/s)
  • * not actively receiving exercise-based swallowing therapy
  • * between the ages of 50 and 90.
  • * Other neurological disorders (e.g., multiple sclerosis, stroke, brain tumor, etc.)
  • * history of head and neck cancer
  • * history of breathing disorders or diseases (e.g., COPD)
  • * history of smoking in the last five years
  • * uncontrolled hypertension
  • * difficulty complying due to neuropsychological dysfunction (i.e., severe depression with \>28 on the Beck Depression Index (BDI-II), dementia with \<19 on the Montreal Cognitive Assessment (MoCA))
  • * allergy to capsaicin or barium
  • * further than 1.5 hours (door to door) distance from either Teachers College, Columbia University or Purdue University.

Ages Eligible for Study

50 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Teachers College, Columbia University,

Michelle Troche, PhD, PRINCIPAL_INVESTIGATOR, Teachers College, Columbia University

Study Record Dates

2027-09-01