RECRUITING

Rehabilitation of Airway Protection in Parkinson's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD. Despite this, a large number of patients with PD do not access specialized services to address these critical deficits. The investigators will examine the comparative effectiveness of a novel treatment paradigm delivered in-person versus via telehealth in persons with PD, as well as the role of patient burden and treatment adherence on outcomes; thus, the proposed research is relevant to public health and in line with NIH's mission to identify novel, efficacious, and accessible rehabilitation strategies for short- and long-term improvement of dysfunctional airway protection in PD.

Official Title

Rehabilitation of Airway Protection in Parkinson's Disease: Comparing In-person and Telehealth Service Delivery Models

Quick Facts

Study Start:2022-08-11
Study Completion:2027-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05700825

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosed with PD (Hoehn and Yahr Stages II-IV)126,127 confirmed by a Movement Disorders fellowship trained neurologist having reviewed the video recorded Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) assessment for each participant and using strict UK brain bank criteria
  2. * airway protective deficits as defined as a minimum of penetration of thin liquids (penetration-aspiration score\>3) as determined by instrumental swallowing assessment and/or dystussia as determined by voluntary cough assessment (PEFR ≤4.1 L/s)
  3. * not actively receiving exercise-based swallowing therapy
  4. * between the ages of 50 and 90.
  1. * Other neurological disorders (e.g., multiple sclerosis, stroke, brain tumor, etc.)
  2. * history of head and neck cancer
  3. * history of breathing disorders or diseases (e.g., COPD)
  4. * history of smoking in the last five years
  5. * uncontrolled hypertension
  6. * difficulty complying due to neuropsychological dysfunction (i.e., severe depression with \>28 on the Beck Depression Index (BDI-II), dementia with \<19 on the Montreal Cognitive Assessment (MoCA))
  7. * allergy to capsaicin or barium
  8. * further than 1.5 hours (door to door) distance from either Teachers College, Columbia University or Purdue University.

Contacts and Locations

Study Contact

Michelle Troche, PhD
CONTACT
212-678-3072
uadlab@tc.columbia.edu

Principal Investigator

Michelle Troche, PhD
PRINCIPAL_INVESTIGATOR
Teachers College, Columbia University

Study Locations (Sites)

Purdue University
West Lafayette, Indiana, 47907
United States
Teachers College, Columbia University
New York, New York, 10027
United States

Collaborators and Investigators

Sponsor: Teachers College, Columbia University

  • Michelle Troche, PhD, PRINCIPAL_INVESTIGATOR, Teachers College, Columbia University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-08-11
Study Completion Date2027-09-01

Study Record Updates

Study Start Date2022-08-11
Study Completion Date2027-09-01

Terms related to this study

Additional Relevant MeSH Terms

  • Parkinson Disease
  • Dysphagia