Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk

Description

Patients with Type 1 Diabetes Mellitus (T1DM) have a higher risk of low-trauma (osteoporotic) fracture that is 7-12 times higher than non-diabetics. The bone density of people with Type 1 Diabetes is higher at the time of fracture than in non-diabetics. This suggests the presence of underlying bone tissue mechanical defects. The potential benefits to participants would be knowledge gained about their bone density and the results of laboratory tests. On a wider scale, there may be general benefits to society because the knowledge gained from this study may help better understand the effects of diabetes on bone health

Conditions

Type 1 Diabetes, Osteopenia, Bone Loss, Fractures, Bone

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Study Overview

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Study Details

Study overview

Patients with Type 1 Diabetes Mellitus (T1DM) have a higher risk of low-trauma (osteoporotic) fracture that is 7-12 times higher than non-diabetics. The bone density of people with Type 1 Diabetes is higher at the time of fracture than in non-diabetics. This suggests the presence of underlying bone tissue mechanical defects. The potential benefits to participants would be knowledge gained about their bone density and the results of laboratory tests. On a wider scale, there may be general benefits to society because the knowledge gained from this study may help better understand the effects of diabetes on bone health

Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk

Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk

Condition
Type 1 Diabetes
Intervention / Treatment

-

Contacts and Locations

Omaha

Creighton University Osteoporosis Research Center, Omaha, Nebraska, United States, 68122

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. No chronic disease diagnoses that may affect bone, as confirmed by the PI.
  • 2. Normal clinical history, physical, and clinical laboratory exam (except for usual complications of a 10+-year diabetic, i.e., \~minimal neuropathy or retinopathy, known, but asymptomatic mild vascular disease, etc.)
  • 3. Glomelular Filtration Rate (GFR) \>45 ml/min (Renal Association lower limit for "mild" kidney failure).
  • 4. Willingness to sign a consent form.
  • 5. Willingness to undergo a transilial bone biopsy incision that yields 2 bone specimens.
  • 6. No abnormalities in clinical blood chemistry measurements (small, age-related decreases in GFR, will be permitted).
  • 7. Caucasian
  • 1. Dual-energy x-ray absorptiometry (DXA) measures (BMD, gm/cm) must be within +/- 15% in total hip.
  • 2. Body mass index (BMI) must be within +/-10%.
  • 3. Age must be within +/- 5 years.
  • 4. Caucasian
  • 1. Women who have had Type 1 diabetes for less than 10 years.
  • 2. Non-insulin dependent Type 1 diabetic.
  • 3. Less than 50 years old.
  • 4. Less than 5 years post menopausal.

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Creighton University,

Mohammed Akhter, PhD, PRINCIPAL_INVESTIGATOR, Creighton University Osteoporosis Research Center

Study Record Dates

2025-01