This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.
Venous Thromboembolism, Deep Venous Thrombosis, Post-Thrombotic Syndrome
This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.
DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
-
Honor Health, Scottsdale, Arizona, United States, 85258
UCI Medical Center, Orange, California, United States, 92868
Vascular and Interventional Specialists of Orange County, Orange, California, United States, 92868
University Of Colorado, Denver, Colorado, United States, 80045
Yale University, New Haven, Connecticut, United States, 06520
MedStar Health Research Institution, Washington, District of Columbia, United States, 20010
Manatee Memorial Hospital, Bradenton, Florida, United States, 34208
Lakeland Vascular Institute, Lakeland, Florida, United States, 33805
HCA Florida Largo Hospital, Largo, Florida, United States, 33770
Sarasota Memorial Hospital, Sarasota, Florida, United States, 34239
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
No
Inari Medical,
Steven Abramowitz, MD, PRINCIPAL_INVESTIGATOR, MedStar Health Research Institution
Xhorlina Marko, MD, PRINCIPAL_INVESTIGATOR, Henry Ford Health
Stephen Black, MD, PRINCIPAL_INVESTIGATOR, St Thomas' Hospital (UK)
2025-10-31