The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.
Juvenile Huntington Disease, Juvenile-Onset Huntington Disease
The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.
Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
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University of California Davis, Sacramento, California, United States, 95817
University of Iowa Hospitals and Clinics, Department of Psychiatry, Iowa City, Iowa, United States, 52242
Columbia University Medical Center, New York, New York, United States, 10027
Children's Hospital of Philadelphia with the University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19146
Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232
University of Texas Health Science Center at Houston, Houston, Texas, United States, 77030
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
6 Years to 30 Years
ALL
No
University of Iowa,
Peggy C Nopoulos, MD, PRINCIPAL_INVESTIGATOR, University of Iowa
2026-08-31