RECRUITING

Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.

Official Title

Longitudinal Assessment of Brain Structure and Function in Juvenile Onset Huntington's Disease (JoHD)

Quick Facts

Study Start:2023-04-17
Study Completion:2026-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05707663

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:6 Years to 30 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Clinical diagnosis of JoHD
  2. * Aged 6-30
  1. * Metal in body
  2. * History of head trauma, brain tumor, seizures or epilepsy unrelated to JoHD
  3. * History of major surgery or serious chronic medical conditions other than JoHD

Contacts and Locations

Study Contact

Study Staff
CONTACT
866-514-0858
kids-johd@uiowa.edu
Sonia Slevinski, MS
CONTACT
3193538529
sonia-slevinski@uiowa.edu

Principal Investigator

Peggy C Nopoulos, MD
PRINCIPAL_INVESTIGATOR
University of Iowa

Study Locations (Sites)

University of California Davis
Sacramento, California, 95817
United States
University of Iowa Hospitals and Clinics, Department of Psychiatry
Iowa City, Iowa, 52242
United States
Columbia University Medical Center
New York, New York, 10027
United States
Children's Hospital of Philadelphia with the University of Pennsylvania
Philadelphia, Pennsylvania, 19146
United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37232
United States
University of Texas Health Science Center at Houston
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: University of Iowa

  • Peggy C Nopoulos, MD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-17
Study Completion Date2026-08-31

Study Record Updates

Study Start Date2023-04-17
Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

  • JoHD
  • JHD
  • Juvenile Huntington Disease
  • Juvenile Huntington's Disease
  • Juvenile-onset Huntington Disease

Additional Relevant MeSH Terms

  • Juvenile Huntington Disease
  • Juvenile-Onset Huntington Disease