Striated Esophageal Motor Function Modulation in Health and Disease

Description

The investigators hypothesize that striated esophagus deglutitive motor function is modulated by pharyngeal phase swallowing biomechanics.

Conditions

Dysphagia, Esophageal

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Study Overview

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Study Details

Study overview

The investigators hypothesize that striated esophagus deglutitive motor function is modulated by pharyngeal phase swallowing biomechanics.

Characterization of the Striated Esophagus (St.Eso) Deglutitive Motor Function and Its Modulation by Pharyngeal Phase Swallow Biomechanics

Striated Esophageal Motor Function Modulation in Health and Disease

Condition
Dysphagia, Esophageal
Intervention / Treatment

-

Contacts and Locations

Milwaukee

Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 53086

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy subjects aged 18 to 90 years.
  • * Patents with dysphagia but normal high resolution esophageal manometric findings defined by the Chicago classification.
  • * Anyone less than 18 years old.
  • * Patients with recent head and neck cancer (\<1 month post-surgery or \<3 months post-chemo radiation.
  • * Patients suffering from muscle diseases like muscular dystrophies, myopathies.
  • * Patients with neuro-muscular junction disorders myasthenia gravis, Eaton-Lambert disorders.
  • * Patients having history of allergy to lidocaine or barium.
  • * Patients who are pregnant or lactating.
  • * Patients who are medically unstable.
  • * Patients who are unable to apply the exerciser independently or with the help of a caregiver.
  • * Patients who lack cognition.

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Medical College of Wisconsin,

Reza Shaker, PRINCIPAL_INVESTIGATOR, Medical College of Wisconsin

Study Record Dates

2026-04