Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC

Description

To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.

Conditions

Spinal Disease

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Study Overview

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Study Details

Study overview

To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.

Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC

Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC

Condition
Spinal Disease
Intervention / Treatment

-

Contacts and Locations

Houston

M D Anderson Cancer Center, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age ≥ 18 years old
  • 2. Radiographically documented disease of the spine within 4 weeks of registration (candidates with or without epidural disease allowed)
  • 3. Candidate for spine SRS/SBRT as determined by treating Radiation Oncologist or Multidisciplinary Spine Conference review
  • 4. Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
  • 5. Diagnosis of cancer documented
  • 6. Motor strength ≥ 4 out of 5 in the extremity affected by the level of spinal disease planned for radiation
  • 7. Karnofsky Performance score (KPS) ≥ 40 or ECOG score ≤ 3
  • 1. Patients with highly radiosensitive histologies likely to respond to conventional radiation therapy alone (ie lymphoma, multiple myeloma, etc)
  • 2. Patients who are unable to undergo MRI of the spine with contrast
  • 3. Patients who are pregnant

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

M.D. Anderson Cancer Center,

Debra N. Yeboa, MD, PRINCIPAL_INVESTIGATOR, M.D. Anderson Cancer Center

Study Record Dates

2026-01-31