Platelet-Directed Whole Blood Transfusion Strategy for Malaria

Description

Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.

Conditions

Severe Malaria, Thrombocytopenia

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Study Overview

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Study Details

Study overview

Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.

Clinical and Translational Investigations of Severe Malaria Pathophysiology [Parent Study Protocol]

Platelet-Directed Whole Blood Transfusion Strategy for Malaria

Condition
Severe Malaria
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \<5 years
  • * Platelet count ≤75,000/uL
  • * Hemoglobin \>5 and ≤9 g/dL
  • * P. falciparum parasitemia ≥500 parasites/uL
  • * Diagnosis of severe malaria meeting World Health Organization (WHO) criteria
  • * Ability and willingness of the legal guardian to comply with study protocol for the duration of the study
  • * Residence within health clinic catchment area
  • * Signed informed consent obtained from the parent or legal guardian of the participant
  • * Residence in foster care or children otherwise under government supervision
  • * Residence outside the hospital catchment area, or plan to leave the area
  • * Presence of any other condition or abnormality which, in the opinion of the investigator, would compromise the safety of the participant or the quality of the data
  • * Any contraindication to whole blood transfusion

Ages Eligible for Study

6 Months to 59 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins Bloomberg School of Public Health,

Matthew M Ippolito, MD, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2027-04-30