The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis

Description

The experiment outlined in this proposal is designed to test the hypothesis that herpesvirus suppression by the systemic anti-herpesvirus valacyclovir (Valtrex) can significantly help to arrest the progressive course of severe marginal periodontitis in adult patients. A prospective, randomized, placebo-controlled, double-blind, clinical trial is employed to test this hypothesis.

Conditions

Severe Periodontitis

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Study Overview

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Study Details

Study overview

The experiment outlined in this proposal is designed to test the hypothesis that herpesvirus suppression by the systemic anti-herpesvirus valacyclovir (Valtrex) can significantly help to arrest the progressive course of severe marginal periodontitis in adult patients. A prospective, randomized, placebo-controlled, double-blind, clinical trial is employed to test this hypothesis.

The Efficacy of Systemic Valacyclovir (Valtrex) to Arrest Further Progression of Severe Periodontitis

The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis

Condition
Severe Periodontitis
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients must be systemically healthy, Class I dental category.
  • * Involved teeth must have periodontal disease detectible by periodontal examination.
  • * Subjects with deep vertical periodontal lesions (\>6 mm) showing no radiographic crestal alveolar lamina dura
  • * Presence of any disease or medication that alters the immune system or interferes with healing ability Smokers (more than 10 cigarettes per day)
  • * External or internal tooth resorption
  • * Tooth perforation from the pulp cavity through the tip of the root exposing the tissue to material in the oral cavity.
  • * Pregnant or nursing mothers because hormonal factors may influence the condition.
  • * Allergies or adverse reactions to valacyclovir.
  • * Patients under the age of 18.
  • * Patients with renal impairment or reduced renal function.
  • * Patients requiring hemodialysis or peritoneal dialysis.

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, San Francisco,

Mike Sabeti, DDS, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2024-03-01