UPURS Trial for Patient-centered Management of Symptomatic Obstructing Stones

Description

A prospective, non-blinded, randomized controlled trial studying the management of symptomatic ureteral stones. This study will compare upfront ureteroscopy vs observation and delayed intervention for patients presenting to the emergency department with a symptomatic ureteral stone.

Conditions

Ureteral Stone

Study Overview

Study Details

Study overview

A prospective, non-blinded, randomized controlled trial studying the management of symptomatic ureteral stones. This study will compare upfront ureteroscopy vs observation and delayed intervention for patients presenting to the emergency department with a symptomatic ureteral stone.

Upfront vs Postponed Ureteroscopy (UPURS) Trial for Patient-centered Management of Symptomatic Obstructing Stones

UPURS Trial for Patient-centered Management of Symptomatic Obstructing Stones

Condition
Ureteral Stone
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Presenting to the Emergency Department (ED)
  • * Adult (\> 18 yo)
  • * ≥5mm ureteral stone diagnosed on CT scan
  • * Presence of symptoms (pain, nausea, vomiting, hematuria)
  • * Strict indication for stent
  • * Stone burden not amenable to Ureteroscopy (URS)
  • * Dirty urine analysis (UA) or positive urine culture (UCx)
  • * Transplant kidney
  • * Presence of conduit
  • * Comorbidities not optimized for surgery
  • * Strong preference for surgery or observation

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, San Francisco,

Thomas Chi, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2024-06