Study of Aerobic Training for People Receiving Chemotherapy for Breast Cancer

Eligibility Criteria

• * Aged ≥18 years
• * Female
• * Diagnosed with primary breast cancer as defined by one of the following:
• * Histological confirmation
• * As per standard of care imaging
• * Scheduled to receive neoadjuvant/adjuvant chemotherapy
• * Performing ≤90 minutes of moderate- and/or strenuous-intensity exercise per week, as evaluated by self-report
• * Willingness to comply with all study-related procedures
• * Able to achieve an acceptable peak baseline CPET, as defined by any of the following criteria:
• 1. Achieving a plateau in oxygen consumption, concurrent with an increase in power output;
• 2. A respiratory exchange ratio ≥ 1.10;
• 3. Attainment of maximal predicted heart rate (HRmax) (i.e., within 10 bpm of age-predicted HRmax \[HRmax = 220-Age\[years\]);
• 4. Volitional exhaustion, as measured by a rating of perceived exertion (RPE) ≥ 18 on the BORG scale.
• * Enrollment onto any other interventional investigational study, except interventions determined by the PI not to confound study outcomes
• * Receiving treatment for any other diagnosis of invasive cancer
• * Distant metastatic malignancy of any kind
• * Mental impairment leading to inability to cooperate
• * Any of the following contraindications to cardiopulmonary exercise testing:
• * Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation