Evaluating Combination of Nivolumab and Axatilimab in Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

Eligibility Criteria

• * Subject aged ≥ 18 years.
• * Histologically confirmed relapsed or refractory Classical Hodgkin Lymphoma who have progressed on or after at least one line of prior therapy and have had prior exposure to anti-PD-1/anti-PDL-L1 therapy
• * Partial response or stable disease after at least 4 cycles of anti-PD-1/ anti-PDL-1 therapy such as, but not limited to, nivolumab, pembrolizumab, atezolizumab, tislelizumab, and durvalumab or progression on anti-PD-1/ anti-PDL-1 therapy such as, but not limited to, nivolumab, pembrolizumab, atezolizumab, tislelizumab, and durvalumab. (Notes: prior combination treatment with chemotherapy and an anti-PD-1/anti-PDL-1 therapy is acceptable.)
• * Subject must have at least one measurable area of disease (greater than 1.5 cm longest transverse diameter (LDi) to allow for response assessment and biopsy) by Lugano Criteria
• * Subjects with prior history of allogeneic or autologous stem cell transplant must have had at least 90 days since the transplant and must be off of immunosuppressive agents for Graft vs Host disease for at least 2 months.
• * Subjects with a prior autologous transplant are eligible
• * Transplant ineligible subjects are permitted on this study if they have had exposure to anti-PD(L)1 therapy as defined above.
• * ECOG Performance Status ≤ 2.
• * Adequate organ function, without the use of transfusions or growth factors within 7 days, as defined as:
• * Hematologic:
• * Hemoglobin ≥ 8 g/dL (unless bone marrow involved)
• * Absolute Neutrophil Count (ANC) ≥.5 × 10\^9/L unless bone marrow involvement from classical Hodgkin lymphoma
• * Hepatic:
• * Total Bilirubin ≤ 1.5x institutional upper limit of normal (ULN). Exceptions include patients with underlying Gilbert Syndrome in whom ≤ 3x institutional upper limit of normal (ULN) of Total Bilirubin will be allowed.
• * AST(SGOT)/ALT(SGPT) ≤ 3 × Institutional ULN
• * Subjects with liver metastases will be allowed to enroll with AST and ALT levels ≤ 5 x ULN.
• * Renal:
• * Estimated creatinine clearance ≥ 50 mL/min by Cockcroft-Gault formula
• * For female subjects: Negative pregnancy test or evidence of post-menopausal status. The post-menopausal status will be defined as having been amenorrheic for 12 months without an alternative medical cause. The following age-specific requirements apply:
• * Women \< 50 years of age:
• * Luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution; or
• * Underwent surgical sterilization (bilateral oophorectomy or hysterectomy).
• * Women ≥ 50 years of age:
• * Amenorrheic for 12 months or more following cessation of all exogenous hormonal treatments; or
• * Had radiation-induced menopause with last menses \>1 year ago; or
• * Had chemotherapy-induced menopause with last menses \>1 year ago; or
• * Underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy, or hysterectomy).
• * Female subjects of childbearing potential and male subjects with a sexual partner of childbearing potential must agree to use a highly effective method of contraception as described in Section 5.4.1.
• * Recovery to baseline or ≤ Grade 1 CTCAE v5.0 from toxicities related to any prior cancer therapy, unless considered stable or clinically not significant by the treating investigator.
• * Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines.
• * Diagnosis of immunodeficiency or receiving systemic steroid therapy or any other form of immunosuppressive therapy within 14 days prior to the first dose of study drug.
• * The use of physiologic doses of corticosteroids (i.e., ≤10 mg per day of equivalent prednisone) is allowed.
• * Steroids with no or minimal systemic effect (topical, inhalation) are allowed.
• * Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment.
• * Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
• * Previously treated with a CSF-1, CSF-1R, and/or IL-34-blocking agents.
• * Subjects with toxicity from prior treatment that has not resolved to Grade ≤1, except grade 2 peripheral neuropathy, any grade alopecia/vitiligo, grade 3 rash, endocrinopathy managed with replacement therapy.
• * History of Grade ≥3 immune-mediated adverse event attributed to prior immune checkpoint-inhibitor therapy; other than endocrinopathy managed with replacement therapy.
• * History of autoimmune disease, including, but not limited to: myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener granulomatosis, Sjogren syndrome, Guillain-Barre syndrome, multiple sclerosis, vasculitis, or glomerulonephritis, with the following exceptions:
• * History or current clinically significant pulmonary disease, such as obstructive pulmonary disease, bronchospasm, or non-infectious pneumonitis (drug-induced or autoimmune).
• * Prior systemic anti-cancer therapy or any investigational therapy ≤ 14 days or within five half-lives prior to starting study treatment, whichever is shorter. Patients are allowed to be actively receiving anti-PD-1(anti-PD-L1) therapy at the time of enrollment but must stop agents other than Nivolumab prior to dosing with Nivolumab.
• * Evidence of muscle disorders or muscle injury that are known to cause serum creatine kinase (CK) elevation
• * History of PML, HLH, CNS vasculitis, uncontrolled seizure disorder, or neurodegenerative disease.
• * Allogeneic stem cell transplant within 90 days prior to screening or on current treatment for graft vs host disease
• * Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation within 4 weeks or palliative radiation therapy within 2 weeks of the first dose of study drug.
• * Major surgery 4 weeks prior to starting study drug or who have not fully recovered from major surgery.
• * The diagnosis of another malignancy within ≤ 2 years before study enrollment, except for those considered to be adequately treated with no evidence of disease or symptoms and/or will not require therapy during the study duration (i.e., basal cell or squamous cell skin cancer, carcinoma in situ of the breast, bladder or of the cervix, or low-grade prostate cancer with Gleason Score ≤ 6).
• * Known brain metastases or cranial epidural disease.
• * Current evidence of uncontrolled, significant intercurrent illness including, but not limited to, the following conditions:
• * Cardiovascular disorders:
• * Congestive heart failure New York Heart Association Class III or IV, unstable angina pectoris, serious cardiac arrhythmias.
• * Stroke, myocardial infarction (MI), or other ischemic events within 3 months before the first dose.
• * QTc prolongation defined as a QTcF \> 500 ms.
• * Known congenital long QT.
• * Any other condition that would, in the Investigator's judgment, contraindicate the subject's participation in the clinical study due to safety concerns or compliance with clinical study procedures (e.g., infection/inflammation, intestinal obstruction, unable to swallow medication, \[subjects may not receive the drug through a feeding tube\], social/ psychological issues, etc.)
• * Known HIV infection with a detectable viral load within 6 months of the anticipated start of treatment.
• * Active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination, radiographic findings, and TB testing in line with local practice).
• * Clinically significant liver disease, including viral or other hepatitis or cirrhosis.
• * Medical, psychiatric, cognitive, or other conditions that may compromise the subject's ability to understand the subject information, give informed consent, comply with the study protocol or complete the study.
• * Known prior severe hypersensitivity to nivolumab or SNDX-6352 or any component in its formulations (NCI CTCAE v5.0 Grade ≥ 3).
• * Subjects taking prohibited medications as described in Section 6. A washout period of prohibited medications for a period of at least five half-lives or as clinically indicated should occur before the start of treatment.