Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

Description

The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.

Conditions

Heart Failure With Preserved Ejection Fraction, Obesity

Talk to us

Study Overview

On this page

Study Details

Study overview

The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.

Targeting Breathing Limitations to Improve Functional Outcomes in Heart Failure With Preserved Ejection Fraction (HFpEF)

Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

Condition
Heart Failure With Preserved Ejection Fraction
Intervention / Treatment

-

Contacts and Locations

Dallas

UT Southwestern Medical Center, Dallas, Texas, United States, 75390

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * signs and symptoms of heart failure
  • * an ejection fraction \> 0.50;
  • * objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization
  • * healthy volunteers
  • * age \< 55 years
  • * BMI \> 50 kg/m2
  • * Atrial fibrillation with poorly controlled heart rate
  • * phosphodiesterase type 5 (PDE5) inhibitor use
  • * severe valvular disease
  • * severe Chronic obstructive pulmonary disease (COPD)
  • * Chronic kidney disease (CKD) 4 or higher
  • * any restriction of ambulation and mobility.

Ages Eligible for Study

55 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Tony G Babb, Ph.D., PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center

Bryce N Balmain, Ph.D., PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center

Study Record Dates

2026-03-31