Ocular Blood Flow Imaging for Glaucoma Assessment

Description

The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management. The main question it aims to answer are: * Can the investigators use blood flow to discriminate between eyes with early-stage glaucoma and variable-matched controls? * Can the investigators validate that the XyCAM FC simultaneously captures both stereo fundus photography and ocular blood flow monitoring? Participants will be * measured for their blood pressure, heart rate, height, and weight * dilated with tropicamide * imaged using the XyCAM RI, fundus photography, optical coherence tomography, and standard automated perimetry * imaged using the XyCAM RI while inhaling 100% oxygen through a mask

Conditions

Glaucoma

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management. The main question it aims to answer are: * Can the investigators use blood flow to discriminate between eyes with early-stage glaucoma and variable-matched controls? * Can the investigators validate that the XyCAM FC simultaneously captures both stereo fundus photography and ocular blood flow monitoring? Participants will be * measured for their blood pressure, heart rate, height, and weight * dilated with tropicamide * imaged using the XyCAM RI, fundus photography, optical coherence tomography, and standard automated perimetry * imaged using the XyCAM RI while inhaling 100% oxygen through a mask

Ocular Blood Flow Imaging for Glaucoma Assessment

Ocular Blood Flow Imaging for Glaucoma Assessment

Condition
Glaucoma
Intervention / Treatment

-

Contacts and Locations

Baltimore

University of Maryland Eye Associates at Redwood, Baltimore, Maryland, United States, 21201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 and older with binocular vision
  • * Able to provide informed consent
  • * Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria
  • * The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar)
  • * The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy
  • * The subject has prior ocular disease other than glaucoma
  • * The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye
  • * The subject has more than 15 diopters of refractive error
  • * The subject is a female who is pregnant or nursing
  • * The subject has diabetes mellitus

Ages Eligible for Study

18 Years to 88 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Maryland, Baltimore,

Grace Forbes, MS, STUDY_DIRECTOR, University of Maryland, Baltimore

Study Record Dates

2025-04-30