Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients

Description

We will conduct a two-group randomized controlled trial to examine the eMocha DOT intervention with pediatric HT recipients.In this population, medication nonadherence remains a primary cause of late acute rejection (LAR) episodes, increased number of hospitalizations, graft failure, and patient mortality. Herein, we propose an innovative approach to promote medication adherence and improve patient and graft outcomes.

Conditions

Heart Transplant Rejection, Immune Suppression, Pediatric Heart Transplant, Medication Nonadherence, Health Behavior, Remote Monitoring, Patient Engagement

Study Overview

Study Details

Study overview

We will conduct a two-group randomized controlled trial to examine the eMocha DOT intervention with pediatric HT recipients.In this population, medication nonadherence remains a primary cause of late acute rejection (LAR) episodes, increased number of hospitalizations, graft failure, and patient mortality. Herein, we propose an innovative approach to promote medication adherence and improve patient and graft outcomes.

Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients: Enhancing Technological Innovation and Strengthening the Role of Small Businesses in Meeting Needs of Adolescent Organ Transplant

Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients

Condition
Heart Transplant Rejection
Intervention / Treatment

-

Contacts and Locations

Coral Gables

University of Miami, Miller School of Medicine, Coral Gables, Florida, United States, 33146

Gainesville

University of Florida, Gainesville, Florida, United States, 32610

Hollywood

Joe DiMaggio Children's Hospital, Hollywood, Florida, United States, 33021

Tallahassee

FSU College of Medicine, Tallahassee, Florida, United States, 32306

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Eligible participants are 10-21 years of age
  • * Have received a heart transplant and are followed participating pediatric heart transplant centers
  • * English-speaking or Spanish-speaking
  • * Own a smart-phone or have access to the mobile app through other devices
  • * Are willing to receive information through it
  • * Have a MLVI score of greater than 2.0 over the last year

Ages Eligible for Study

10 Years to 21 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Dipankar Gupta, MD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2026-12-31