Validating Gulf War Illness Blood Biomarkers

Description

The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.

Conditions

Gulf War Syndrome, Gulf War Illness

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Study Overview

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Study Details

Study overview

The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.

Validating Blood Biomarkers of Brain Immune and Metabolic Dysfunction in Gulf War Illness

Validating Gulf War Illness Blood Biomarkers

Condition
Gulf War Syndrome
Intervention / Treatment

-

Contacts and Locations

Palo Alto

Palto Alto Veterans Institute for Research, Palo Alto, California, United States, 94304

Sarasota

The Roskamp Institute, Sarasota, Florida, United States, 34232

Boston

Boston University, Boston, Massachusetts, United States, 02118

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age 35 years or older.
  • 2. For GWI cases, served in the 1990-1991 Gulf War as active duty, national guard, or reserves and meet criteria for the CDC Chronic Multisymptom Illness (CMI) GWI definition or Kansas GWI definition.
  • 3. For controls, must be a veteran in the same age range as those veterans with GWI as defined above.
  • 4. Ability to understand written and spoken English or availability of a legal representative who can understand written or spoken English. Participants and caregiver/informants must be able to read, write and speak the language in which psychometric tests are provided with visual and auditory acuity (corrected) sufficient to allow for accurate testing.
  • 1. Diagnosed or being treated by a physician for any of the following (Steele et al, 2000) and deemed clinically significant per the discretion of the PI:
  • 1. Cancer (except for non-melanoma skin cancers)
  • 2. Chronic infectious disease
  • 3. Problems resulting from postwar injuries.
  • 4. Liver disease
  • 5. Lupus
  • 6. Multiple sclerosis
  • 7. Stroke
  • 8. Serious psychiatric condition (those associated with psychosis and/or for which the respondent had been hospitalized since 1991).
  • 9. Dementia or any type of Parkinson's disease (PD).
  • 2. Hospitalized in the last 5 years for alcohol or drug dependence, depression, or post-traumatic stress disorder (PTSD).
  • 3. Female subject is either pregnant or nursing.

Ages Eligible for Study

35 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Roskamp Institute Inc.,

Laila Abdullah, Ph.D., PRINCIPAL_INVESTIGATOR, The Roskamp Institute

Michael Hoffmann, MD, PRINCIPAL_INVESTIGATOR, The Roskamp Institute

Kim Sullivan, Ph.D, PRINCIPAL_INVESTIGATOR, Boston University

Maheen Adamson, Ph.D., PRINCIPAL_INVESTIGATOR, Palo Alto Veterans Institute of Research

Study Record Dates

2026-03-01