The Ambient Light Multiple Myeloma Study

Description

The aim of this multi-site randomized control trial will be is to assess the impact Systematic lighting on circadian rhythm entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation. To achieve this aim, 200 multiple myeloma patients will receive one of two different light-treatments that are designed to promote circadian rhythm alignment. While receiving these light treatments, participants' sleep efficiency, urine melatonin levels, blood inflammatory cytokine levels and symptoms will be assessed over a 2-month period.

Conditions

Multiple Myeloma

Study Overview

Study Details

Study overview

The aim of this multi-site randomized control trial will be is to assess the impact Systematic lighting on circadian rhythm entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation. To achieve this aim, 200 multiple myeloma patients will receive one of two different light-treatments that are designed to promote circadian rhythm alignment. While receiving these light treatments, participants' sleep efficiency, urine melatonin levels, blood inflammatory cytokine levels and symptoms will be assessed over a 2-month period.

Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden Among Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

The Ambient Light Multiple Myeloma Study

Condition
Multiple Myeloma
Intervention / Treatment

-

Contacts and Locations

New York

Icahn Schoool of Medicine at Mount Sinai, New York, New York, United States, 10029

New York

Memorial Sloan Kettering Cancer Center, New York, New York, United States, 10065

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Multiple Myeloma diagnosis
  • * Scheduled to undergo their first Autologous Stem Cell Transplant procedure.
  • * 21years or older
  • * Able to provide informed consent.
  • * English-language proficient
  • * Previous Autologous Stem Cell Transplant procedure
  • * Pregnancy
  • * Eye diseases which limit the ability of light to be processed
  • * Secondary cancer diagnosis within the last 5 years
  • * Severe sleep disorders
  • * History of bipolar disorder or manic episodes
  • * Severe psychological impairment
  • * Previous use of light therapy
  • * Active infection including COVID-19 infection

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Icahn School of Medicine at Mount Sinai,

Mariana Figueiro, PhD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Study Record Dates

2027-06-30