Liver Cirrhosis Network Cohort Study

Eligibility Criteria

• * Age ≥ 18 years
• * Willing to provide samples at baseline
• * Cirrhosis
• 1. At least one liver biopsy within 5 years prior to consent showing either: a) Metavir stage 4 fibrosis; Ishak Stage 5-6 fibrosis OR
• 2. At least 2 of the following:
• 1. Evidence on imaging: Nodular liver with either splenomegaly or recanalized umbilical vein within the past year 2. Liver stiffness: VCTE within one year prior to consent or during Screening ≥12.5 kPa or MRE within one year prior to consent or during Screening ≥5 kPa 3. Evidence of varices demonstrated on imaging or endoscopy within 3 years prior to consent or during Screening 4. Either: FIB-4\>2.67 or platelets \<150/mL within 6 months prior to consent or during Screening
• * Known and documented prior or current hepatocellular carcinoma (HCC) or cholangiocarcinoma
• * Known transjugular intrahepatic portosystemic shunt (TIPS), balloon retrograde transvenous obliteration (BRTO) or porto-systemic shunt surgery regardless of time of occurrence
• * Known prior solid organ transplant or bone marrow transplant
• * Current participation in active medication treatment trials at the time of consent for LCN Cohort Study
• * Prisoners or individuals with more than 180 days incarceration pending due to difficulty with visits
• * Bariatric surgery in the last 180 days prior to consent
• * Known history of fontan procedure-associated liver disease (FALD)
• * Known current medical or psychiatric conditions which, in the opinion of the investigator, would make the participant unsuitable for the study or interfere with or prevent follow-up per protocol
• * Current liver-unrelated end-stage organ failures (Dialysis, stage 3-4 congestive heart failure (CHF), current chronic obstructive pulmonary disease (COPD) on home oxygen, current known active malignancy besides non-melanomatous skin cancer or carcinoma in situ)
• * Documented history of acute alcohol-associated hepatitis (according to NIAAA criteria as described in the MOP) in the 180 days prior to consent
• * Documented current or continued signs and symptoms of acute Wilson disease (acute liver failure, acute neurological deficits, hemolysis)
• * In patients with primary sclerosing cholangitis (PSC): Current active cholangitis with 90 days prior to consent
• * Documented cardiac cirrhosis
• * Known recent (within the last 365 days) or present hepatic decompensation with ascites/hydrothorax, hepatic encephalopathy or variceal bleeding
• * Known or documented habitual non-adherence to previous research studies or medical procedures or unwillingness to adhere to protocol (e.g., unwilling to obtain consent or samples)
• * Current model for end-stage liver disease (MELD-Na) cut off ≥ 15
• * Current Child-Turcotte-Pugh (CTP) B or C
• * Current known Hepatitis C Virus (HCV) without sustained virologic response (SVR)
• * Current known quantifiable Hepatitis B Virus (HBV) viral DNA on therapy with ongoing adherence on suppressive therapy
• * In patients with autoimmune hepatitis: serum aspartate aminotransferase (AST) \> 2 times upper limit of normal (ULN) within 60 days prior to consent or during Screening
• * In patients living with HIV: cluster of differentiation 4 (CD4) + T cell count less than 100 cells/mm3 within 60 days prior to consent or during Screening