RECRUITING

High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study

Conditions

Pediatric Brain Tumor Exercise Program HIIT Program Pediatric Brain Tumor Survivors

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine whether a 16-week virtual, home-based, high-intensity interval training (HIIT) exercise program will improve physical, cognitive, and emotional health among young adult survivors of pediatric brain tumors. The names of the study interventions involved in this study are/is: * High-Intensity Interval Training (HIIT)

Official Title

High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study (HYPE)

Quick Facts

Study Start:2023-12-04

Study Completion:2025-05-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05740839

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 39 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Written informed consent prior to any study-related procedures. * At time of study are a young adult, aged 18-39 years. * Histologically diagnosed brain tumor during childhood (diagnosed ≤18 years). * Are at least 2 years post tumor-directed therapy. * The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to undergo a pregnancy test and to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately. * Medically cleared to participate in exercise by their referred physician or a certified clinical exercise physiologist. * Are without medical conditions that could exacerbate with exercise, such as bone disease (excluding bone metastases) at imminent risk of fracture or uncontrolled cardiopulmonary or metabolic diseases. * Speak English and/or Spanish. * Currently participate in less than or equal to 60 minutes of moderate or vigorous structured exercise/week. * Does not smoke or vape (no smoking/vaping during previous 12 months). * Willing to travel to DFCI for necessary data collection. * Ability to understand and the willingness to sign a written informed consent document.	* Diagnosis of primary spinal cord tumor. * Pre-existing medical conditions such as uncontrolled cardiopulmonary disease, or metabolic diseases that could exacerbate with exercise. * Patients with active malignancies. * Patients who are pregnant. * Actively on a weight loss diet. * Participate in more than 60 minutes of moderate or vigorous structured exercise/week. * Currently smokes or vapes. * Unable to travel to DFCI for necessary data collection. * May not be able to comply with the safety monitoring requirements of the study in the opinion of the investigator.

Inclusion Criteria

Exclusion Criteria

* Written informed consent prior to any study-related procedures.
* At time of study are a young adult, aged 18-39 years.
* Histologically diagnosed brain tumor during childhood (diagnosed ≤18 years).
* Are at least 2 years post tumor-directed therapy.
* The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to undergo a pregnancy test and to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately.
* Medically cleared to participate in exercise by their referred physician or a certified clinical exercise physiologist.
* Are without medical conditions that could exacerbate with exercise, such as bone disease (excluding bone metastases) at imminent risk of fracture or uncontrolled cardiopulmonary or metabolic diseases.
* Speak English and/or Spanish.
* Currently participate in less than or equal to 60 minutes of moderate or vigorous structured exercise/week.
* Does not smoke or vape (no smoking/vaping during previous 12 months).
* Willing to travel to DFCI for necessary data collection.
* Ability to understand and the willingness to sign a written informed consent document.

* Diagnosis of primary spinal cord tumor.
* Pre-existing medical conditions such as uncontrolled cardiopulmonary disease, or metabolic diseases that could exacerbate with exercise.
* Patients with active malignancies.
* Patients who are pregnant.
* Actively on a weight loss diet.
* Participate in more than 60 minutes of moderate or vigorous structured exercise/week.
* Currently smokes or vapes.
* Unable to travel to DFCI for necessary data collection.
* May not be able to comply with the safety monitoring requirements of the study in the opinion of the investigator.

Contacts and Locations

Study Contact

Christina Dieli-Conwright, PhD, MPH

CONTACT

617-582-8321

ChristinaM_Dieli-Conwright@dfci.harvard.edu

Principal Investigator

Christina Dieli-Conwright, PhD, MPH

PRINCIPAL_INVESTIGATOR

Dana-Farber Cancer Institute

Study Locations (Sites)

Dana Farber Cancer Institute

Boston, Massachusetts, 02215

United States

Collaborators and Investigators

Sponsor: Dana-Farber Cancer Institute

Christina Dieli-Conwright, PhD, MPH, PRINCIPAL_INVESTIGATOR, Dana-Farber Cancer Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-12-04

Study Completion Date2025-05-31

Study Record Updates

Study Start Date2023-12-04

Study Completion Date2025-05-31

Terms related to this study

Keywords Provided by Researchers

Pediatric Brain Tumor
Exercise Program
HIIT Program
Pediatric Brain Tumor Survivors

Additional Relevant MeSH Terms

Pediatric Brain Tumor