High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study

Eligibility Criteria

• * Written informed consent prior to any study-related procedures.
• * At time of study are a young adult, aged 18-39 years.
• * Histologically diagnosed brain tumor during childhood (diagnosed ≤18 years).
• * Are at least 2 years post tumor-directed therapy.
• * The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to undergo a pregnancy test and to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately.
• * Medically cleared to participate in exercise by their referred physician or a certified clinical exercise physiologist.
• * Are without medical conditions that could exacerbate with exercise, such as bone disease (excluding bone metastases) at imminent risk of fracture or uncontrolled cardiopulmonary or metabolic diseases.
• * Speak English and/or Spanish.
• * Currently participate in less than or equal to 60 minutes of moderate or vigorous structured exercise/week.
• * Does not smoke or vape (no smoking/vaping during previous 12 months).
• * Willing to travel to DFCI for necessary data collection.
• * Ability to understand and the willingness to sign a written informed consent document.
• * Diagnosis of primary spinal cord tumor.
• * Pre-existing medical conditions such as uncontrolled cardiopulmonary disease, or metabolic diseases that could exacerbate with exercise.
• * Patients with active malignancies.
• * Patients who are pregnant.
• * Actively on a weight loss diet.
• * Participate in more than 60 minutes of moderate or vigorous structured exercise/week.
• * Currently smokes or vapes.
• * Unable to travel to DFCI for necessary data collection.
• * May not be able to comply with the safety monitoring requirements of the study in the opinion of the investigator.