Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

Description

The primary objective of this study is to determine the longer-term (6 months) effect of CPAP therapy on change in 24-hour mean blood pressure (24hMBP) in OSA subjects with the excessively sleepy symptom subtype.

Conditions

Obstructive Sleep Apnea

Talk to us

Study Overview

On this page

Study Details

Study overview

The primary objective of this study is to determine the longer-term (6 months) effect of CPAP therapy on change in 24-hour mean blood pressure (24hMBP) in OSA subjects with the excessively sleepy symptom subtype.

Effect of CPAP on 24-Hour Blood Pressure in the Excessively Sleepy Obstructive Sleep Apnea Subtype

Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

Condition
Obstructive Sleep Apnea
Intervention / Treatment

-

Contacts and Locations

Columbus

The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio, United States, 43221

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-75 years
  • * Moderate-severe OSA (defined as ODI ≥10 events/hour) via Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) done based on clinical grounds
  • * Excessively sleepy subtype determined by patient-reported symptoms
  • * Willing to accept CPAP therapy
  • * An elevated baseline office BP defined as ≥120 or ≥80 mmHg
  • * Planned PAP (CPAP or bi-level PAP) treatment by treating provider
  • * Recent changes (within 3 months) to BP medications among those who are on these medications
  • * Unable to apply ABPM cuff
  • * Current use of CPAP or other OSA treatments
  • * Resting, awake SaO2 \<90% or use of home oxygen therapy
  • * New York Heart Association (NYHA) categories III-IV of heart failure
  • * Presence of Cheyne-Stokes Respiration (CSR) in sleep study identified by typical crescendo-decrescendo pattern of respiration with associated apneas and/or hypopneas in the absence of inspiratory flow limitation
  • * Predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events \[apnea or hypopnea\])
  • * Life expectancy \<2 years
  • * Pregnancy
  • * Clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
  • * Systolic BP \> 180 mmHg

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Ohio State University,

Ulysses Magalang, MD, PRINCIPAL_INVESTIGATOR, Ohio State University

Study Record Dates

2028-03-01