rTMS and Rehabilitation for Individuals With CRPS Type 1

Description

Subjects with complex regional pain syndrome (CRPS) Type 1 will be randomized to receive repeated transcranial magnetic stimulation (rTMS) followed by rehabilitation or sham rTMS followed by rehabilitation. Treatment will last for 4 weeks, with the first week including 4 rTMS treatments and 2 rehabilitation treatments. Subsequent weeks will include 2 rTMS treatments followed by 2 rehabilitation treatments. Outcome measures will include pain ratings, PROMIS questionnaires, global rating of change, and grip strength or 1 repetition maximum leg press.

Conditions

Complex Regional Pain Syndrome Type I

Study Overview

Study Details

Study overview

Subjects with complex regional pain syndrome (CRPS) Type 1 will be randomized to receive repeated transcranial magnetic stimulation (rTMS) followed by rehabilitation or sham rTMS followed by rehabilitation. Treatment will last for 4 weeks, with the first week including 4 rTMS treatments and 2 rehabilitation treatments. Subsequent weeks will include 2 rTMS treatments followed by 2 rehabilitation treatments. Outcome measures will include pain ratings, PROMIS questionnaires, global rating of change, and grip strength or 1 repetition maximum leg press.

Repeated Transcranial Magnetic Stimulation and Rehabilitation for Individuals With Complex Regional Pain Syndrome Type 1

rTMS and Rehabilitation for Individuals With CRPS Type 1

Condition
Complex Regional Pain Syndrome Type I
Intervention / Treatment

-

Contacts and Locations

Syracuse

SUNY Upstate Medical Univeristy Institute of Human Performance, Syracuse, New York, United States, 13210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Upper or lower extremity CRPS Type 1 (also called RSD-Reflex Sympathetic Dystrophy) of at least 6 months.
  • * Pain rating on NPRS of at least 4/10
  • * No initiation of a new intervention (i.e., medication, rehab, injections) in the previous 2 months.
  • * No plan to initiate a new intervention during the study treatment timeframe (4 weeks).
  • * A history of seizures or epilepsy
  • * Intracranial metallic devices
  • * Pacemaker
  • * Intrathecal infusion pumps
  • * Brain or spinal cord stimulators with epidural electrodes
  • * Other ferromagnetic metallic intracranial implants
  • * Apparent mental or psychiatric disorder that prevents adequate informed consent
  • * Current pregnancy
  • * Non-English speaking

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

State University of New York - Upstate Medical University,

Adam Rufa, DPT, PhD, PRINCIPAL_INVESTIGATOR, SUNY Upstate Medical Univerity

Study Record Dates

2025-08-01